Breadth Redesign and Detection of Respiratory Syncytial Virus Neutralizing Antibody

Abstract

呼吸道合胞病毒(Respiratorysyncytialvirus)简称RSV,是引起全世界范围内婴幼儿下呼吸道感染的主要原因之一,两岁前的婴幼儿几乎全部感染过RSV,其中约有50%会出现重复感染。最新的全球疾病死亡率分析显示,1月到一周岁的婴幼儿死亡中有约6.7%是由RSV感染造成的。此外,老年人群感染RSV后也会出现严重病症及死亡病例。至今没有安全有效的疫苗上市,唯一获准上市用于预防RSV感染的特异性药物是针对融合蛋白F的中和单抗帕利珠(palivizumab,Synagis®),但由于其中和效价不足,免疫剂量大,生产成本高等原因,目前仅被批准用于降低免疫缺陷和先心病等高危新生儿...Respiratory Syncytial Virus(RSV)is one of the major pathogen which caused lower respiratory tract infection in infants and young children around the world, the infants before 2 years almost infected with RSV, 50% of them will reinfect. In the latest global disease mortality analysis, about 6.7% of children death while one to twelve months were caused by RSV infection. Furthermore, infection in the...学位:理学硕士院系专业:生命科学学院_生物化学与分子生物学学号:2162014115252

    Similar works