Liposome-Based Signal Amplification Method for Portable Detection of Disease Biomarkers

Abstract

高灵敏、高特异、快速检测疾病相关蛋白不仅在医疗保健方面,在临床实践和诊断应用方面也具有重要的意义。即时检测(point-of-caretest)是指能够通过便携式设备快速得到检测结果的一种手段,在日常检测疾病中具有广泛的需求。血糖仪是目前应用最广泛的家用诊断设备之一,可用一滴全血测定血糖,具有操作简单、快速方便、用血量少的优点,但是检测靶标仅限葡萄糖。脂质体是由磷脂分子在水中分散而形成的球形双分子层纳米颗粒,由于其内腔可以包裹大量信号分子而在分析检测方面具有重要的应用。本工作使用脂质体作为信号放大以及转导载体,将检测的蛋白靶标信号转化为血糖仪可以检测到的葡萄糖信号,建立即时检测疾病相关蛋白的通...It is of great significance to detect disease-associated proteins with high sensitivity, selectivity and portability, particularly in clinical practice and diagnostic applications. Point-of-care test (POCT) refers to a mean of real-time acquisition of test results by portable devices, which are highly desired for detection of biomarkers in daily life. The personal glucose meter (PGM) is one of the...学位:理学硕士院系专业:化学化工学院_化学生物学学号:2052013115167

    Similar works