花生四烯酸（Arachidonicacid，ARA）为ω-6高级多不饱和脂肪酸，具有促进婴幼儿脑部发育、调节神经传导、降低胆固醇等多种重要的生理功能，在膳食营养、医药、化妆品等多领域有广泛应用。传统的ARA主要来源于动物油等，难以满足市场需求，利用微生物发酵法生产ARA具有周期短、不受地域限制等优点，成为当前研究的热点之一，而高山被孢霉被认为是ARA的优良生产菌株。 本文以实验室自主分离并鉴定的一株ARA生产菌株—M.alpinaLU166为研究对象，从油脂代谢和ARA合成途径着手，考察了以下几个因素对发酵的影响。首先发现凹槽摇瓶培养可以稳定地控制菌体形态为刺突状小球，这一形态比絮状和大球状...Arachidonic acid is a kind of ω-6 polyunsaturated fatty acid (PUFA), it has many physiological functions, like improving brain development in infants and young children, regulating nerve conduction, and reducing cholesterol levels, so it is widely applied in dietary nutrition, medicine, and cosmetics fields. Traditional ARA mainly comes from animal oils, which is difficult to meet the market dem...学位：工学硕士院系专业：化学化工学院_化学工程学号：2062013115149
