The physiological mechanisms of key factors in IGF/ILP signaling system in the mud crab, Scylla paramamosain

Abstract

胰岛素样生长因子(insulin-likegrowthfactor,IGF)/胰岛素样多肽(insulin-likepeptide,ILP)信号系统在脊椎动物的代谢和生长过程中起着至关重要的调控作用。近年来的研究表明,无脊椎动物中也分布着大量的ILP基因,这些基因及其编码的蛋白参与调控包括代谢、生长、生殖和蜕皮等在内的一系列生物学过程。迄今,有关甲壳动物IGF/ILP信号系统的组成、生物学功能及其信号传导途径的研究很少。 拟穴青蟹(Scyllaparamamosain)是我国东南沿海重要的海水养殖蟹类之一,具有很高的经济价值。本文以拟穴青蟹为研究对象,采用分子生物学、细胞生物学以及生物化学...Insulin-like growth factor (IGF)/insulin-like peptide (ILP) signaling system holds a central position in regulating growth and metabolism in vertebrates. In recent decades, ILPs have been also proved to exist extensively in invertebrates and play critical roles in the regulation of growth, metabolism, reproduction, molt and other behavioral and physiological processes. However, there is little inf...学位:理学博士院系专业:海洋与地球学院_海洋生物学学号:2232013015377

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