Genome-wide DNA Methylation status in Neonates affected by Maternal Organochlorine Pesticides Exposure during Pregnancy

Abstract

研究背景 双对氯苯基三氯乙烷(2,2-bis(chlorophenyl)-1,1,1-trichloroethane,DDTs)是在生产生活中最常见的有机氯农药之一(Organochlorinepesticides,OCPs),其半衰期较长,是一类可以通过食物链传递从而蓄积在脂肪组织、而且具有生物放大效应的有机化合物。而产前母亲与胎儿时刻承受着环境污染物暴露的风险。有的感染,特别是早期感染,可能直接导致怀孕失败与流产,或者造成胎儿畸形。关键问题是,对于大部分没有导致流产与畸形的感染,它们对孩子出生后的一生的疾病(比如免疫疾病)风险会产生重要的影响,而这些影响可能会通过表观遗传学(比如甲基化)...Background 2, 2 bis chlorophenyl-1,1,1-trichloroethane(DDTs) is a kind of common Organochlorine pesticides(OCPs) around environment, and it has a long half-life, which can accumulate in adipose tissue and has biological amplification effect. It is a critical period for the development of fetus during pregnancy, and the epigenome is particularly vulnerable to environmental pollutants in early st...学位:医学硕士院系专业:公共卫生学院_流行病与卫生统计学学号:3262014115054

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