RNA螺旋酶可以通过水解三磷酸腺苷（ATP）供能来催化RNA双链解螺旋，在RNA代谢中发挥重要作用。DHX32是新发现的一种RNA螺旋酶，其广泛分布于体内组织，目前发现DHX32存在两种转录本，一种为DHX32全长，另一种通过可变剪切产生exon4缺失转录本（DHX32Δ4）。有研究表明，DHX32能改变JurkatT细胞对Fas信号的敏感性，通过下调c-FLIPshort的表达，从而促进JurkatT细胞凋亡。有研究表明，DHX32在结直肠癌中上调，且可以促进细胞生长及迁移，而最新的研究提示，DHX32通过β-catenin信号通路促进VEGFA的表达，从而促进肿瘤的生长。因此，DHX32可...RNA helicase can catalyze RNA double-stranded unwind by hydrolyzing adenosine triphosphate (ATP) to play an important role in RNA metabolism. RNA helicase share 8 highly conserved sequences (I, Ia, Ib, II-VI), which are divided into DHX helicase and DDX helicase according to the amino acid sequence of conserved sequence II. DHX32 is a newly discovered RNA helicase, which is widely distributed in v...学位：医学硕士院系专业：公共卫生学院_转化医学学号：3262014115058
