Expression and Characterization of Human Immunodeficiency Virus-1 Membrane Protein gp140 from Mammalian Cells and Generation of Neutralizing Monoclonal Antibodies

Abstract

艾滋病(AcquiredImmuneDeficiencySyndrome,AIDS)是由人类免疫缺陷病毒(HumanImmunodeficiencyVirus,HIV)感染引起的获得性免疫缺陷综合征。艾滋在世界范围内流行,其中主要是1型HIV病毒给人类健康带来严重威胁。据世界卫生组织(WorldHealthOrganization,WHO)报告,自从HIV被发现以来,被感染者已逾7千万人,2015年底全球仍有3千6百多万艾滋患者,15岁至49岁成人HIV感染率高达0.8%[1]。2012至2014年连续三年,我国艾滋病发病超过4万人/年[2]。目前高活性抗逆转录病毒治疗(HighlyActiv...AIDS is an acquired immunodeficiency syndrome caused by HIV (Human Immunodeficiency Virus) infection. AIDS is prevalent in the world, and type 1 HIV virus mainly poses a serious threat to human health. As reported by World Health Organization, there are more than 70 million people who have been infected since the discovery of HIV-1. By the end of 2015, there were still more than 36 million AIDS pa...学位:医学硕士院系专业:公共卫生学院_卫生毒理学学号:3262014115056

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