Molecular Dynamic Simulation on Flexible Binding of Broad-specific Neutralizing Antibody CDR3 with Avian Influenza Virus Receptor Binding Site (RBS) and Structure-based Rational Design of RBS-binding
流感病毒以其持续变异能力和在全球范围内的广泛传播，引发人类呼吸道传染病，严重威胁着人类的健康，是全球公共卫生的重大问题。每年都有大量的人感染流感病毒，或因季节性流感和流感大爆发而死亡。其中，禽流感病毒的威胁，尤其是H5N1型和H7N9型等高致病性禽流感病毒已逐渐成为对人类最具威胁的传染病之一。由于流感病毒的高度变异性，现有的疫苗研发策略需要每年更新流行株，而传统抗病毒药物的治疗效果也会受到影响，因此开发新型抗流感药物是流感防治的迫切需要。 流感病毒包膜外的血凝素蛋白是中和抗体识别的主要靶标，介导流感病毒与宿主细胞结合。血凝素蛋白头部区的受体结合域具有一个凹槽形结构，其保守性位点能与唾液酸受体...Influenza virus evolve and circulate continuesly and widely in the global, causing human respiratory disease which is a serious threat to human health, and it has become a major global public health problem. Every year a large number of people infected with influenza virus, or die from seasonal flu and influenza pandemic. Among them, the threat of avian influenza virus, especially the H5N1 and H7N...学位：医学硕士院系专业：公共卫生学院_转化医学学号：3262014115057
