目的探讨围绝经期女性骨代谢状况与"血瘀"的关联性。方法 132例符合纳入标准的围绝经期女性按年龄每5岁为一组,分为4组,采用电化学发光法检测不同阶段Ⅰ型胶原氨基端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素N-端中分子片段(N-MID)等骨代谢指标,同时检测血液流变学指标,并对其进行"血瘀"量化评分、甲襞微循环评分,相关数据采用多元回归等统计学进行分析。结果 PINP与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01);β-CTX与血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01),与红细胞电泳时间存在显著负相关(P<0.01),与全血低切粘度、红细胞刚性指数存在正相关(P<0.05);N-MID与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著正相关(P<0.01)与全血低切粘度存在正相关(P<0.05)。结论围绝经女性骨代谢状况与"血瘀"关系密切,血瘀是导致围绝经女性骨代谢状况发生变化而发生骨质疏松的重要因素之一。Objective To discuss the correlation between bone metabolism and blood stasis in perimenopausal women. Me thods132 cases of perimenopausal women meeting the inclusion criteria were divided into 4 groups by every 5-year age. Type I collagen amino-terminal propeptide( PINP),carboxy-terminal peptide β special sequence( β-CTX),and molecular osteocalcin N- terminal fragment( N-MID) were detected with electrochemical luminescence at different stages. Blood rheology,blood stasis quantitative score,and microcirculation score were simultaneously detected. Data were analyzed using multiple regression method. Re sults PINP was positively correlated with shear viscosity of whole blood,blood stasis quantitative score,and microcirculation score( P <0. 01). β-CTX was positively correlated with blood stasis quantitative score,microcirculation score,lowshear whole blood viscosity,and erythrocyte rigidity index( P < 0. 01),but was negatively correlated with erythrocyte electrophoresis time( P <0. 01). N-MID was positively correlated with whole blood viscosity,blood stasis quantitative score,microcirculation score( P <0. 01),and lowshear whole blood viscosity( P < 0. 05). Conclusion Bone metabolism and blood stasis are closely related in perimenopausal women. Blood stasis is one of the important factors leading to osteoporosis and change of bone metabolism in perimenopausal women.福建省医学创新课题(2012-CXB-26);; 福建省中医药课题(WST201205
