Establishment of a method for detection of serum SCCAg based on Chemiluminescence

Abstract

鳞状上皮细胞癌(鳞癌,或称表皮样癌)是一种多发生于肺部、皮肤、肛门、颈、喉、鼻和膀胱等有复层鳞状上皮组织的恶性肿瘤,发病死亡率高,危害十分严重。目前认为,发展和应用有效的肿瘤标记物诊断试剂开展早期诊断和病情监测是预防和治疗肿瘤疾病的有效措施。 鳞状上皮细胞癌抗原最早发现于子宫颈癌组织,包括两种同源分子SCCA1和SCCA2,二者具有92%的氨基酸同源性和高度相似的抗原表位特征。研究已显示,SCCAg是一种重要的肿瘤标记物,与多种器官的鳞状上皮细胞癌有较密切关系。血清SCCAg水平可用于有效辅助宫颈癌、头颈部癌、肺非小细胞肺癌、结直肠癌等多种鳞状上皮细胞癌的临床诊断、病情监测和预防判断。目前,...Squamous cell carcinoma (epidermoid carcinoma) is a malignant tumors mostly occurrs in the lungs, skin, anus, neck, throat, nose and bladder, where covered with squamous epithelium tissues. Because of the high mortality, the squamous cell carcinoma is very harmful. At present, it is believed that the development and application of effective tumor markers for early diagnosis and disease monitoring ...学位:医学硕士院系专业:公共卫生学院_转化医学学号:3262014115057

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