Jiadifenolide是一个从我国特有药物假地枫皮中分离得到的结构新颖的seco-prezizaanes型倍半萜类化合物,具有一个高度氧化的五环笼状结构,7个连续手性中心.它在较低浓度下有效促进神经元的生长,被认为是一种小分子营养剂,具有治疗神经退行性疾病的潜力.总结了过去五年间关于此分子的合成研究进展.Jiadifenolide, a new seco-prezizaane-type sesquiterpenoid, was isolated from Chinese unique medicine Illicium jiadifengpi. It contains a highly oxygenated cagelike architecture with seven contiguous stereocenters. It displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neuro-degenerative diseases. This review summarizes the synthetic efforts towards jiadifenolide in the last five years.国家自然科学基金(Nos.21142007,21272194,21572187,U1405228);; 中央高校基本科研业务费专项资金(No.20720160025);; 教育部长江学者和创新团队发展计划资助项目~
