目的观察大剂量国产胸腺肽对慢性活动性乙肝患者血清细胞因子的影响，探讨胸腺肽治疗慢性乙肝的机制。方法选择慢性活动性乙肝患者34例，分成两组：胸腺肽组19例，一般护肝组15例。比较观察治疗前后患者血清IFN—α、sIL－2r、TNF，和β2－MG为指标的变化。结果胸腺肽治疗后，患者PBMIFN—α诱生能力较治疗前上升119．99％，血清sIL—2r和TNF含量分别下降了35．56％和41．80％，治疗初期对β2—MG有提升作用。一般护肝组对慢性乙肝患者PBMIFN－α诱生能力和下调血清sIL-2r、TNF的作用弱于胸腺肽，对β2—MG指标没有影响。结论胸腺肽治疗慢性乙肝疗效与促进IFN产生和下调sIL-2r和TNF等多项免疫调节功能有关。Aim To dtudy the effects of high-dose thymosin on the cytokine conentration in serum of the patients with chronic hepatitis B and its therapy mechanism.Methods 34 patients with chronic active hepatitis B were divided into two groups; 19 patients were treated with thymosin and 15 patients with common drugs of protecting liver cells (PLC) .Level changes of IFN-α,sIL-2r, TNF, and β2-MG in the patients' serum were analyzed comparatively before and after treatment.Results After treating of thymosin, ability of induced-producing IFN-αin patients' PBMC was increased 119.99% over before treatment; concentrations of sIL-2r anu TNF in serum were decreased by 33.56% and 41.80%, respectively;and β2-MG in serum were increased in the early days of thymosin treatment.PLC showed similar, weaker effect on IFN-α, sII-2r, and TNF than that thymosin did; but no significant effects on β2-MG. Conclusions Mechanism of thymosin against HBV reproducing is relative to the the effets enhancing IFN-α producing abilities ,downing the serum levels of sIL-β2r and TNF,and so on.厦门市科委资助!Z9880
