Studies on the Chemical Composition of Sea Cucumber Mensamaria Intercedens Ⅲ. Immunomodulative Effects of PMI-1

Abstract

研究了二色桌片参多糖-1(PMI-1)在体内、体外的免疫调节作用.结果表明,二色桌片参多糖-1体外能促进小鼠脾淋巴细胞增殖,促进小鼠脾淋巴细胞分泌IL-2;体内能显著促进迟发型超敏反应,增加脾指数、胸腺指数;具有显著的免疫增强作用。The immunoactivities of PMI-1 are studied in vivo and in vitro. PMI-1(5. 50. 100u g/mL ) in vitro could promote the proliferation of mice lymphocyte, and increase IL-2 production as well. In vivo, PMI-1 could significantly improve the delayed-type hypersensitivity (DTH) degree and the weights of spleen and thymus, although it has little effect on the production of hemolysin antibodies. The results indicate that PMI-1 could remarkedly enhance the immunofunction in mice

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