采用巯基化合物自组装 /共价键合反应的逐层固定方法将双链 DNA固定到金表面得到 DNA修饰电极 ,并对该电极表面进行了电化学和 X射线光电子能谱表征 .研究了电极表面固定化 DNA的表面分子杂交 .对开发电化学基因诊断芯片和基因传感器具有一定意义Double stranded DNA was covalently immobilized onto gold surfaces by layer by layer immobilization method, and the surfaces were characterized by electrochemical and XPS methods. The surface molecular hybridization of DNA was studied on these functionized surfaces. This work might be fundamental for electrochemical gene chips and genosensors for disease diagnosis.国家自然科学基金! (批准号 :2 9773 0 3 4 ;3 9770 2 2 0 );; 国家杰出青年科学基金! (批准号 :2 0 0 2 5 3 11);; 教育部“高等学校
