This dissertation presents three observational projects designed to characterize the outer disks of nearby galaxies (beyond the optical radius R25). Until very recently, outer disks remained an elusive and poorly-understood component of disk galaxies. We first present a Large Binocular Telescope (LBT) optical imaging survey of nearby outer disks to examine the basic properties of this component. Our LBT observations indicate that most nearby galaxies host an outer disk with star formation occurring at a very low level. We detect hundreds of outer disk star clusters and show that they typically have masses between 100–10,000 solar masses and ages up to a Gyr. The clusters are born in groups that can remain clustered for a Gyr or more, while the clusters slowly evaporate stars into a diffuse stellar component. The clusters appear to form from localized overdensities in the gas distribution primarily associated with spiral structure. The clusters extend to 2R25 in our sample. We find that some clusters may also reside well outside of their host galaxy's gas disk. Our second project is a kinematic study of H-alpha knots in the outer disk of the large, isolated, face-on galaxy NGC 628, using Inamori Magellan Areal Camera and Spectrograph (IMACS) observations from the Magellan telescope. This galaxy shows a kinematically cold outer disk (velocity dispersion < 11 km/s) with a mass density Sigma = 7.5 solar masses per square pc. Our observations cannot exclude uniform star formation lasting a Hubble time in this outer disk and confirm that this component is an extension of the kinematically-cold inner disk. Our third project is a search for molecular emission in the outer disk of NGC 628, using the sensitive Atacama Large Millimeter Array (ALMA) receiver on the Submillimeter Telescope (SMT). We did not detect emission from our outer disk pointings, though we are able to provide useful estimates for future ALMA observations of outer disk knots. Our SMT observations indicate that the H2 / HI ratio is ∼100x lower in the outer disk than in the inner disk, which likely explains, at least in part, the trend towards smaller clusters and lower star formation rates at larger radii