The differential quadrature (DQ) method is able to obtain quite accurate numerical solutions of differential equations with few grid points and less computational effort. However, the traditional DQ method is convenient only for regular regions and lacks upwind mechanism to characterize the convection of the fluid flow. In this paper, an upwind local radial basis function-based DQ (RBF-DQ) method is applied to solve the Navier-Stokes equations, instead of using an iterative algorithm for the primitive variables. The non-linear collocated equations are solved using the Levenberg-Marquardt method. The irregular regions of 2D channel flow with different obstructions situations are considered. Finally, the approach is validated by comparing the results with those obtained using the well-validated Fluent commercial package
