A vortex-induced vibration experiment considers drilling conditions has not been conducted. A new experimental facility was designed to investigate effect of drilling pipe on vortex-induced vibration. Results show that vortex-induced vibration can be inhibited with the increasing drilling pipe tension. Strain amplitude decrease with the increase in drilling pipe tension and strain amplitude decreases significantly with increasing pipe tension at high current speed. Drilling pipe tension does not affect the dominant vibration frequency. Interaction between the IL and CF vibration and the multi-modal phenomenon are more apparent for the periodically contacting and colliding between the drilling pipe and risers