A Dietrich

A Emadian

A Flint

AA Mulligan

AE Troy

AJ Page

AJ Stunkard

B Burton-Freeman

BM Appelhans

C Chang

C-X Yi

CL Triplitt

D Jenkins

D Matthews

D Nunan

D Zahn

DS Ludwig

E Harju

EJ Bryant

F Huang

FA Koopman

FR Bornet

GJ Morton

H Du

H Young

IR Contento

J Burneo

J Sobocki

JF Davis

JF Thayer

JS Bodenlos

K Polonsky

KA Bollen

KL Teff

L Lähteenmäki

L Maayan

L Schwingshackl

LA Frohman

M Camilleri

M Stubbs

MG Sarr

ML McCullough

MN Jarczok

MP Tarvainen

MR Carnethon

P Daniel

RD Cook

S Bingham

S Ikramuddin

S Seino

SA Bingham

SA French

SA Shikora

T Akhavan

TN Akbaraly

VA Pavlov

Scientific Reports

Hayley Young

Cronfa at Swansea University

Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial

AbstractReducing the glycemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn modulates vagal tone; a phenomenon associated with glucoregulation. This double blind randomised controlled trial explored for the first time the influence of disinhibited eating and vagal tone (heart rate variability (HRV)) on hunger and the postprandial response to GL. Blood glucose (BG) and hunger were measured 30 and 150 min after consumption of water, glucose or isomaltulose (low glycemic sugar). After consuming glucose, independently of BMI or habitual diet, those with the highest levels of disinhibition had higher BG levels after thirty minutes (B = 0.192, 95% CI LL. 086, UL 0.297), and lower BG after one hundred and fifty minutes (B = −0.240, 95% CI LL −0.348, UL −0.131). BG was related to hunger but only in low disinhibited eaters. Disinhibited eaters were characterised by a reduced HRV which was related to greater BG excursions (B = 0.407, 95% CI LL 0.044, UL 1.134). These findings highlight novel mechanisms by which disinhibited eating leads to obesity and insulin resistance. This trial was registered at clinicaltrials.gov NCT02827318.</jats:p

Hayley A. Young

Heather Watkins

Crossref

Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial

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Cronfa at Swansea University

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