A. Ciavarella

A. Lombardi

E. Ferrazzi

E. Iurlaro

F. Blasi

F. Mosca

F. Peyvandi

I. Martinelli

M. Ossola

R. Erra

English

AIR Universita degli studi di Milano

Contents lists available at ScienceDirect
Thrombosis Research
journal homepage: www.elsevier.com/locate/thromres
Letter to the Editors-in-Chief
Pulmonary embolism in a young pregnant woman with COVID-19
On March 29, 2020, a 17-year-old obese woman (BMI 32 Kg/m2)
was admitted at 29 weeks of gestation to our COVID-19 Maternity Hub
in Milan for fever, mild dyspnea and rhinitis in the last three days. Her
past medical history was unremarkable and she had a negative family
history of venous thromboembolism. Her body temperature was
37.3 °C, heart and respiratory rates, and oxygen saturation were
normal. A nasopharyngeal swab revealed a SARS-CoV-2 infection. On
March 30, her respiratory function suddenly worsened and she started
oxygen supplementation with 2 l per minute via nasal cannula. On April
1, she developed tachypnea (30 breaths per minute) and oxygen flow
was increased to 6 l per minute via Venturi mask. Blood culture de-
monstrated a Staphylococcus aureus bacteremia. The same day antith-
rombotic prophylaxis with enoxaparin 4000 IU once daily was started.
On Apr 4, the patient developed an acute respiratory failure and un-
derwent a chest CT-scan that showed a segmental pulmonary embolus
in the right superior lobe, other than a ground-glass opacification and
early parenchymal consolidation at lower lobes of the lungs. Laboratory
tests did not vary compared to those at admission, except for the neu-
trophil/lymphocyte ratio and an increase of ferritin concentration
(Table 1). At 29 weeks and 6 days, the patient delivered by urgent
cesarean section for worsening dyspnea. A female new-born of 1490 g
(appropriate for gestational age) was admitted to Neonatal Intensive
Care Unit and did well. In the postpartum, enoxaparin was increased to
therapeutic doses of 8000 IU twice daily. The patient required a non-
invasive ventilation with CPAP, and a gradual improvement of her re-
spiratory function occurred in the following days. On April 9, CPAP
ventilation was discontinued and oxygen supplementation with 3 l per
minute via nasal cannula was sufficient to reach a SpO2 of 99%. On
April 14 the patient was discharged.
Despite the young age and a personal and family history negative
for thrombosis, this young obese woman with COVID-19 and
Staphylococcus aureus infection developed pulmonary embolism.
Although the embolus was small and did not worsen coagulation la-
boratory parameters, it caused a severe impairment of patient's clinical
conditions and prompted an urgent timing of delivery. There is stem-
ming evidence that pulmonary embolism is a complication of COVID-19
[1]. Obese pregnant women with COVID-19 may have a particularly
high risk of pulmonary embolism because of coexisting prothrombotic
conditions. This should be considered for tailoring antithrombotic
prophylaxis.
Funding
The authors received no specific funding for this work.
Declaration of competing interest
The authors do not declare any conflict of interest.
Table 1
Laboratory findings at admission and at worsening of respiratory function.
Mar 29, 2020 -
admission
Apr 4, 2020 - diagnosis
of pulmonary embolism
White-cell count (per mm3) 6910 6022
Differential count (per mm3)
Total neutrophils 5660 3910
Total lymphocytes 770 1830
Total monocytes 470 430
Platelet count (per mm3) 300,000 335,000
Hemoglobin (g/l) 85 91
Albumin (g/l) 34 24
Alanine aminotransferase (U/l) 18 12
Aspartate aminotransferase (U/l) 29 ND
Lactate dehydrogenase (U/l) 168 223
Creatinine (μmol/l) 48 47
EGFR (mil/min/1.73 m2) 144 145
Prothrombin time (sec) 10.9 9.8
Activated partial-thromboplastin
time (sec)
31.8 27.2
Fibrinogen (g/l) 6.02 5.43
D-dimer (mg/l) 16.4 15.8
Serum ferritin (μg/l) 117 418
Procalcitonin (ng/ml) ND 0.10
C-reactive protein (mg/l) 28.5 28.1
https://doi.org/10.1016/j.thromres.2020.04.022
Received 16 April 2020; Accepted 17 April 2020
Thrombosis Research 191 (2020) 36–37
Available online 20 April 2020
0049-3848/ © 2020 Elsevier Ltd. All rights reserved.
T
References
[1] F.A. Klok, Kruip MJHA, N.J.M. van der Meer, et al., Incidence of thrombotic com-
plications in critically ill ICU patients with COVID-19, Thromb Res (2020), https://
doi.org/10.1016/j.thromres.2020.04.013.
Ida Martinellia,⁎, Enrico Ferrazzib, Alessandro Ciavarellaa,
Roberta Errab, Enrico Iurlarob, Manuela Ossolab, Andrea Lombardic,
Francesco Blasid, Fabio Moscae, Flora Peyvandia,f
a Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, A. Bianchi
Bonomi Hemophilia and Thrombosis Center, Milan, Italy
b Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Unit of
Obstetrics, Department of Mother Neonate and Child, Mangiagalli Centre,
Milan, Italy
c Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Infectious
Diseases Unit, Milan, Italy
d Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Internal
Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center,
Department of Pathophysiology and Transplantation, University of Milan,
Milan, Italy
e Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Neonatal
Intensive Care Unit, Department of Clinical Sciences and Community Health,
Milan, Italy
fDepartment of Pathophysiology and Transplantation for Health, University
of Milan, Milan, Italy
E-mail address: ida.martinelli@policlinico.mi.it (I. Martinelli).
⁎ Corresponding author at: Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, via Pace 9, Milan 20122, Italy.
Letter to the Editors-in-Chief Thrombosis Research 191 (2020) 36–37
37


Pulmonary embolism in a young pregnant woman with COVID-19

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Pulmonary embolism in a young pregnant woman with COVID-19

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