utilit\ue0 dell'utilizzo di dulaglutide in real world in pazienti con diabete tipo 

Avogaro, A

D'Ambrosio, M

Fadini, GP.

Frison, V

Lapolla, A

Morieri, ML

Paccagnella, A

Rigato, M

Simioni, N

Tadiotto, F

Context: In randomized controlled trials (RCTs) on type 2 diabetes (T2D) patients, the glucagonlike peptide-1 (GLP-1) receptor agonist (GLP-RA) dulaglutide reduced HbA1c and body weight, but generalizability of such findings to real-world T2D patients is challenging. Objective: We evaluated effectiveness of dulaglutide in routine clinical practice, especially in subgroups of patient that are underrepresented in RCTs. Design: Retrospective multicenter study. Setting: Diabetes outpatient clinics. Patients and intervention: All consecutive patients who initiated dulaglutide between 2015 and 2018. Main outcome measures: Changes in HbA1c and body weight were assessed up to 30 months after baseline. Effectiveness was analyzed in patient subgroups according to: prior use of GLP- 1RA, persistence on treatment and dose, age, sex, disease duration, renal function, obesity, cardiovascular disease, or concomitant use of insulin or sulphonylurea. Results: From a background population of 83,116 pati..

Morieri ML

Frison V

Rigato M

D'Ambrosio M

Tadiotto F

Paccagnella A

Simioni N

Lapolla A

Avogaro A

Fadini GP.

Archivio istituzionale della ricerca - Università di Padova

Effectiveness of dulaglutide in the real world and in special populations of type 2 diabetic patients

Effectiveness of dulaglutide in the real world and in special populations of type 2 diabetic patients.

Effectiveness of dulaglutide in the real world and in special populations of type 2 diabetic patients.

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Archivio istituzionale della ricerca - Università di Padova