Sousa Basto, Artur

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Journal of the Portuguese Society of Dermatology and Venereology

505Carta ao EditorRevista SPDV 73(4); Artur Sousa Basto; Carcinoma epidermóide.CARCINOMA EPIDERMÓIDE     Artur Sousa Basto, MDPrivate Dermatologist, Braga, Portugal  PALAVRAS-CHAVE – Carcinoma Epidermóide; Imiquimod; Mebutato de Ingenol. EPIDERMOID CARCINOMA  KEY-WORDS – Epidermoid Carcinoma; Imiquimod; Ingenol Mebutate. Direito à privacidade e consentimento escrito / Privacy policy and informed consent: Os autores declaram que pediram consentimento ao doente para usar as imagens no artigo. The authors declare that the patient gave written informed consent for the use of its photos in this article.Recebido/Received - Julho/July 2015; Aceite/Accepted – Agosto/August 2015Correspondência: Dr. A. Sousa Basto Rua Cândido de Oliveira 130, 1ºC4715-012 Braga, PortugalEmail: sousabasto@hotmail.com Editor,Imiquimod is a topical immune response modifier used in a patient-applied cream to treat genital warts, actinic ke-ratosis and superficial basal cell carcinomas. It activates the immune system through the toll-like receptor 7 (TLR-7).1Ingenol mebutate is another topically applied drug that has been approved for the treatment of actinic keratosis and is currently being investigated for the treatment of non-mela-noma skin cancer.1Recently I examined a 93 years’ old woman in a pre-co-ma state, with a round tumor on the zygomatic area of the right side of her face with almost six months of evolution. The tumor had a hemispheric shape with a central ulceration and the size of a chestnut (Fig.s 1and 2). A biopsy showed an epi-dermoid carcinoma.It was not possible to transfer the patient to a surgical center in order to remove the tumor, taking into account the pre-coma state of the patient. Besides, the skin was extremely thin and surgery would be very difficult in such conditions.Therefore, we used imiquimod, which reduced the size of the tumor in half. Then, we decided to apply ingenol mebuta-te 150mcg/g during the three following days and the tumor completely regressed in two weeks (Fig. 3).Fig 1506Carta ao EditorWe decided to communicate this case in support of those who are using these drugs in the treatment of non-melanoma skin cancer. We found no similar case but we may recom-mend trying the association of these two drugs when the sur-gery is not easy and risky.REFERENCIE1. Micali G, Lacarrubba F, Nasca MR, Ferraro S, Schwartz RA. Topical pharmacotherapy for skin cancer: part II. Clinical applications. J Am Acad Dermatol. 2014; 70:979.e1-12.Revista SPDV 73(4); Artur Sousa Basto; Carcinoma epidermóide.Fig 2 Fig 3 

CARCINOMA EPIDERMÓIDE

https://revista.spdv.com.pt/index.php/spdv/article/download/496/379

CARCINOMA EPIDERMÓIDE

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Journal of the Portuguese Society of Dermatology and Venereology