This is an accepted manuscript of an article published in the International Journal of Development Research on 30/05/2020.
The accepted version of the publication may differ from the final published version, accessible at https://www.journalijdr.com/vitamin-d-has-aetiological-role-dementias-myth-or-factVitamin D is produced through the cutaneous transformation of 7-dehydrocholesterol by UVB-irradiation with multiple neurotrophic and neuroprotective functions, while regulating calcium-mediated neuronal excitotoxicity. Vitamin D acts mainly through binding to intracellular Vitamin D receptor (VDR) with a possible involvement of vitamin D receptor (VDR) and vitamin D-binding protein (VDBP). This is a review of evidence for the aetiological role of vitamin D in dementias and other neurological disorders.
There is contradictory evidence regarding vitamin D supplementation in the prevention of dementia progression. Adding vitamin D to the standard medications used in dementia may have a future role in dementia management.
Key words: Vitamin D; Dementia; Aetiology; Memantine; Dementia Medications; Neurodegenerative Disorders; Vitamin D Receptor; Neurological Disorder
