Extracellular Scavenging of Oxygen Radicals Produced by Polymorphonuclear Leukocytes - The Relevance to Rheumatoid Arthritis

Abstract

This thesis is the account of laboratory research which I undertook in the Department of Medical Biochemistry, University of Wales College of Medicine between October 1981 and September 1983, while funded by an Arthritis and Rheumatism Council Research Training Fellowship. The aim of the work was to investigate the role of oxygen radicals produced by polymorphonuclear leukocytes (PMN) in the pathogenesis of rheumatoid arthritis, and in particular to establish the availability of these reactive moieties for extracellular tissue damage