Cysteine proteases are implicated in a wide range of biological processes, which makes them an important factor in the pathogenesis of many diseases. Dysregulation of protease activity can lead to various diseases such as cancer, osteoporosis, neurological disorders and cardiovascular diseases. Furthermore, cysteine proteases have been proved to play a critical role in the life cycle of parasitic infections, an issue that grows every year due to increasing human migration. Therefore, cysteine proteases show great potential as targets for medicinal chemists.
The following work aims to address this area of research through the synthesis of non-natural amino acid derived thiosulfonate warheads
