#I. A survey of the literature dealing with
antimalarial compounds is given, with special
reference to the relationship between chemotherapeutic
activity and chemical constitution.
#II. The relation between various isomeric
derivatives of m-phenanthroline is discussed and
the constitution of certain new compounds and of
orientation has been
established.
#III. The condensation of m -amino acetanilide
with ethyl aceto acetate has been carried out and
the product cyclised by the method. of Conrad and.
Limpach. It has been shown that the compound so
obtained is 5-acetylamino-4-hydroxy-2-methyl
quinoline and not the isomeric 7-acetylamino
derivative.
#IV. The following chloro derivatives of m-phenanthroline
have been prepared: 2-methyl-4-chloro-5:6, 21:3'-pyrido quinoline; 2-methyl-4-chloro7:8,2':3'-pyrido quinoline; 2-chloro-4-methyl-7:8,2'3'-pyrido quinoline; 2-chloro-5:6,2':
3'-pyrido quinoline and 2-chloro-7:8,2':3'- pyrido quinoline.
It is shown that the chloro n-phenanthroline
described in D.R.P. 654,444 (C. 1938, I, 2023)
and assumed to be 2-chloro-5:6,2':3'-pyrido
quinoline does in fact have this structure, and
is not the isomeric 2-chloro-7:8,2':3'-pyrido
quinoline.
#V. The first four of the above chloro compounds
were condensed with the appropriate bases to yield
respectively: 4-(ß-diethylamino ethylamino) -2-
-5:6,2':3'-pyrido quinoline and 4-(α-methyl-
δ-diethylamino butyl amino)-2-methyl-5:6,2':3'-pyrido quinoline; 4-(ß-diethylamino ethyl amino)-2-methyl-7:8,2':3'-pyrido quinoline and 4-(α-methyl-δ-diethylamino-butyl amino)-7:8,2':3'-
pyrido quinoline; 2-(P-diethylamino ethyl amino)-4-methyl- 7:8,2' :3'- pyrido quinoline and 2-(α-methyl-δ-diethylamino-butyl amino)-7:8,21:31-pyrido
quinoline; 2-(ß-diethylamino ethyl amino)-5:6,2':
3'-pyrido quinoline and 2-(α-methyl-δ-diethylamino-butyl amino)- 5:6,2:3'- pyrido quinoline
