Aichelburg

Arien

Benmarzouk-Hidalgo

Brantsaeter

Brinkhof

Cannon

Deayton

Dodt

Ford

Griffiths

Gronborg

Hardie

Honge

Hønge

Jespersen

Kaplan

Levitsky

Lucas

Martinson

Mayaphi

Mhiri

Murray

Nogalski

Nordentoft

Olesen

Oliveira

Rabenau

Raufman

Rennert

Rouse

Rowland-Jones

Schnepf

Silva

Singh

Steininger

Wittkop

English

OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.</p

Grønborg, Helene L

Jespersen, Sanne

Egedal, Johanne H

Correia, Faustino G

Medina, Candida

Krarup, Henrik

Hønge, Bo L

Wejse, Christian

VBN (Videnbasen)  Aalborg Universitets forskningsportal

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau:a cross-sectional study

Helene L. Grønborg

Sanne Jespersen

Johanne H. Egedal

Faustino G. Correia

Candida Medina

Henrik Krarup

Bo L. Hønge

Christian Wejse

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Crossref

Tropical Medicine & International Health

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

https://vbn.aau.dk/ws/files/293586563/Prevalence_and_clinical_characteristics_of_CMV_coinfection_among_HIV_infected_individuals_in_Guinea_Bissau_A_cross_sectional_study.pdf

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau:a cross-sectional study

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VBN (Videnbasen) Aalborg Universitets forskningsportal

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