This present study arose following the hypothesis that vascular
occlusion and progressive ischaemia were involved in the pathogenesis
of navicular disease. The study was designed so that an evaluation
of the radiographic and pathological changes in the navicular bones
and surrounding structures could be carried out in horses in which
a clinical diagnosis of navicular disease had been made and these
compared with the results of similar examinations in control horses
with no evidence of lameness. Using clinical criteria combined with
an objective method of assessment based on radiographic findings,
the effects of different treatments of navicular disease were
examined with particular emphasis on oral warfarin therapy.
Of the 265 horses examined clinically, 90 constituted a
control population, 151 had a lameness which was diagnosed as
navicular disease and the remaining 24 horses, although they
displayed a fore foot lameness similar to navicular disease, it
fulfilled less than half the required clinical criteria and they
were thus designated "not yet diagnosed" NYD.
No one clinical feature was diagnostic of navicular disease
in itself but it was concluded that the clinical diagnosis should
be based on the presence of a number of clinical signs, and the
response to a number of diagnostic aids.
It is considered from this study that the particular type of
work performed by a horse does not in itself predispose the animal
to navicular disease but that irregular work, and sudden or
prolonged periods of rest in an otherwise hard worked horse are
predisposing factors.
From radiographic examinations of the navicular bones of the
horses in this study, no particular radiographic feature was
considered to be diagnostic of navicular disease. The significant
radiographic changes in the navicular bone in navicular disease were,
an increase in number and change in shape and distribution of the
distal nutrient foramina, the presence of nutrient foramina in the
proximal border and radiolucent areas in the body of the bone.
Some of these radiographic changes were found in the navicular bones
of the control horses.
The distal nutrient foramina were identified and classified
according to their morphology and position and 7 basic types were
found. Distal nutrient foramina, shaped other than conical were
considered as abnormal.
Examination of serial radiographs at intervals showed that the
distal nutrient foramina could increase in number and show changes in
their shape which were part of a progressive series of changes.
An objective method of assessing radiographs of the navicular
bone was developed which consisted of a scoring system based on the
number shape and anatomical position of the distal nutrient foramina.
Significantly higher scores per navicular bone were found in the
navicular disease group than in the control group, although there
was a degree of overlap between the groups. It is considered that
this navicular scoring system provides a useful method of evaluating
radiographs of the navicular bone, but should not be used as the sole
criterion in the diagnosis of navicular disease.
Pathological examination, which included gross pathology,
radiography, microangiography, fluorescent microscopy following the
administration of intra-vital fluorochrome bone labels to a number
of horses, and light microscopy, showed that pathological changes
were present in all of the navicular bones and deep flexor tendons
in the navicular disease cases, and also in a small number of control
cases. These pathological changes were present to different degrees
and could be fitted into a pattern of increasing severity. The main
pathological changes found in the navicular bone were, degeneration
of the fiborcartilage, disruption and loss of the subchondral bone
plate of the fibrocartilage surface, an overall increase in the
vascularisation, remodelling or the trabeculae in the medulla, and
in the deep flexor tendon there was disruption of tendon fibres.
A significant positive correlation was found between the degree of
gross pathological change present in the navicular bones and deep
flexor tendons and the navicular score.
No evidence of occlusive vascular disease or of bone necrosis
was found in any of the navicular bones examined in this study.
These- results do not therefore support the hypothesis that occlusive
vascular disease and progessive ischaemia are involved in the
pathogenesis of navicular disease. However, the overall increase in
vascularisation and active bone remodelling, in the absence of
obvious vascular occlusion and bone necrosis suggests that hyperaemia
rather than ischaemia may be involved in the pathogenesis of this
condition. Although the cause of the hyperaemia has not been
established, there is evidence that active and/or passive hyperaemia
could be involved.
The treatments used in this study were, rest, oral warfarin
therapy, corrective shoeing, phenylbutazone, neurectomy and isoxsuprine
hydrochloride. The results of the treatments were assessed clinically
and radiographically using the navicular scoring system. No
significant difference was found between the results of the different
treatments at 3-4, and 6-8 months from the start of treatments, but
significantly better results were found with warfarin therapy, 1 year
from the start of treatments.
It is considered from the results of this study that the
positive effects of warfarin and isoxsuprine hydrochloride in the
treatment of navicular disease may not be related to the
anticoagulant or vasodilator effects but may be associated with
their ability to reduce blood viscosity and thus improve blood flow