The purpose of this review is to analyze evidence on prevalence of opioid, alcohol and marijuana use during pregnancy and answer the PICOT question: In pregnant women addicted to or using marijuana, opioids, and alcohol, how do non-pharmacological interventions, compared to standard care of pharmacological interventions alone, affect health outcomes in mothers and neonates between birth to hospital discharge? Diagnosis of substance use disorder is increasing and with it comes increased risk of complications to mother and neonate including neonatal abstinence syndrome (NAS), fetal alcohol syndrome (FAS) and other negative neonatal and maternal outcomes. Evidence was identified on the online databases, PubMed and CINAHL. Twenty studies from 2013-2018 were reviewed. Interventions included specialized comprehensive care, individual care, motivational interviewing (MI), and brief intervention. There was limited research about the topic, indicating a need for more research to find the most effective non-pharmacological interventions for these populations
