Kerrostalon peruskorjauksen hankesuunnitelma on esimerkki-korjauskohteen hankesuunnitelma, mitä voidaan käyttää hyväksi kun tehdään yksilöidyn kohteen Hankesuunnitelmaa. Materiaalin tarkoituksena on selvittää Hankesuunnitelman sisältöä ja antaa taustatietoa korjausrakentamisen tutkimuksesta ja yleisistä ratkaisuista. Hankesuunnitelmassa on esitetty kolme erilaista linjasaneerauskonseptia, useita energiatehokkuutta parantavia konsepteja, hissirakennusvaihtoehto ja vaihtoehto, missä peruskorjausta voidaan osin rahoittaa rakentamalla lisäkerros. Materiaali auttanee myös taloyhtiötä niiden tehdessä päätöksiä eri korjauskonseptien välillä

Affolabi, Dissou

André, Emmanuel

Antoine, Rudy

Brites, Daniela

de Jong, Bouke Catherine

Diels, Maren

Duthoy, Stéphanie

Fissette, Kristina

Gagneux, Sebastien

Gaudin, Cyril

Habimana, Yves Mucyo

Jouet, Agathe

Kaswa, Michel K.

Loiseau, Chloé

Marceau, Michael

Mazarati, Jean Baptiste

Meehan, Conor Joseph

Menardo, Fabrizio

Mulders, Wim

Ngabonziza, Jean Claude Semuto

Niyigena, Esdras Belamo

Rigouts, Leen

Ssengooba, Willy

Supply, Philip

Tzfadia, Oren

Nature Communications

Ngabonziza, JCS

Loiseau, C

Marceau, M

Jouet, A

Menardo, F

Tzfadia, O

Antoine, R

Niyigena, EB

Mulders, W

Fissette, K

Diels, M

Gaudin, C

Duthoy, S

Ssengooba, W

André, E

Kaswa, MK

Habimana, YM

Brites, D

Affolabi, D

Mazarati, JB

de Jong, BC

Rigouts, L

Gagneux, S

Meehan, CJ

Supply, P

Nottingham Trent Institutional Repository (IRep)

A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle

edoc

English

Abstract: The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle. The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC

Loiseau, Chloe

Duthoy, Stephanie

Andre, Emmanuel

Institutional Repository Universiteit Antwerpen

Ilveskoski, Olli

Theseus

Kerrostalon peruskorjauksen hankesuunnitelma

YesThe human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.This work was supported by EDCTP2 grant DRIA2014-326—DIAMA of the European Union, the Belgian General Directorate for Development Cooperation (PhD fellowship to J.C.S.N.), Grant ANR-16-CE35-0009 from Agence Nationale de la Recherche, the Swiss National Science Foundation (Grants 310030_188888, IZRJZ3_164171, IZLSZ3_170834 and CRSII5_177163), and the European Research Council (309540-EVODRTB). The views and opinions of authors expressed herein do not necessarily state or reflect those of EDCTP. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript

Ngabonziza, J.C.S.

Loiseau, C.

Marceau, M.

Jouet, A.

Menardo, F.

Tzfadia, O.

Antoine, R.

Niyigena, E.B.

Mulders, W.

Fissette, K.

Diels, M.

Gaudin, C.

Duthoy, S.

Ssengooba, W.

André, E.

Kaswa, M.K.

Habimana, Y.M.

Brites, D.

Affolabi, D.

Mazarati, J.B.

de Jong, B.C.

Rigouts, L.

Gagneux, S.

Meehan, Conor J.

Supply, P.

Bradford Scholars

International audienceThe human-and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region-involved in the cobalamin/vitamin B12 synthesis-and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle

Kaswa, Michel,

HAL Descartes

The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC

Jean Claude Semuto Ngabonziza

Chloé Loiseau

Michael Marceau

Agathe Jouet

Fabrizio Menardo

Oren Tzfadia

Rudy Antoine

Esdras Belamo Niyigena

Wim Mulders

Kristina Fissette

Maren Diels

Cyril Gaudin

Stéphanie Duthoy

Willy Ssengooba

Emmanuel André

Michel K. Kaswa

Yves Mucyo Habimana

Daniela Brites

Dissou Affolabi

Jean Baptiste Mazarati

Bouke Catherine de Jong

Leen Rigouts

Sebastien Gagneux

Conor Joseph Meehan

Philip Supply

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http://www.theseus.fi/bitstream/10024/71416/3/HAMK_Kerrostalon_peruskorjaus_2014_ekirja.pdf

Kerrostalon peruskorjauksen hankesuunnitelma

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