Introduction: To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC).
Materials and Methods: Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA \u3c10 ng/mL, Gleason score \u3c8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1–5, criterion 1 stringent (Gleason score 6 + ≤5mm total max core length PC + ≤3mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume \u3c2.5mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume \u3c0.7 mL).
Results: 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC.
Conclusions: Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies. prostate cancer screening (PSA), testing practices, United Kingdom, Australia, qualitative stud
