Effects of lipoteichoic acid and lipopolysaccharide on SHED

Abstract

Stem cells from human exfoliated deciduous teeth (SHED) are a readily accessible source of stem cells. SHED are exposed to pathogen associated molecular patterns (PAMPs), such as lipoteichoic acid (LTA) and lipopolysaccharide (LPS) during pulpal inflammation and subsequent tissue regeneration. However, little is known about effects of PAMPs on SHED. We examine effects of PAMPs on SHED viability and proliferation, we also report on SHED expression of Toll-like receptors (TLRs) and SHED growth factor secretion in response to LTA