On the mathematical modelling of metabolic pathways and its use in the identification of the most suitable drug target.

Abstract

Parasitic diseases are a present and worsening threat to human health and welfare around the globe. Yet current products and tools for the treatment of most parasitic diseases are predominantly limited in scope, effect and availability. Drug resistance is spreading rapidly, the development of new drugs is not keeping pace with need, and many potential vaccines have not been meeting expectations. This report details the proceedings of a meeting on "Drugs against parasitic diseases", held in Montpellier, France (24-26 1999). The goal of the meeting was the production of a basic framework to better coordinate and guide research and development of antiparasitic drugs. The meeting addressed various questions concerning drug discovery and development, with particular attention being paid to novel strategies and new technologies. There was a special focus on the promise and pitfalls of parasite genomics. The papers presented at the meeting (and published in this report) cover a selection of top priorities that would benefit from immediate R&D activities. They also attempt to provide guidance that could be used to accelerate the general development of antiparasitic drugs

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