Asymmetrische Synthese von Dehydropiperidinonen und polysubstituierten Pyrrolidinen

Abstract

Nitrogen containing heterocycles are an important class of organic compounds due to their interesting pharmacological properties. Therefore, the aim of this research project was to develop a new asymmetric pathway to yield dehydropiperidinones and pyrrolidines. The synthesis of dehydropiperidinones succeeded via a thiourea catalyzed Mannich aza-Achmatowicz reaction sequence. Furthermore, an efficient domino Mannich aza-Michael reaction towards the synthesis of polyfunctionalized pyrrolidines was developed