Clancy, J

Deuchars, J

Deuchars, S

Murray, A

Aaron Murray

Jennifer Clancy

Susan Deuchars

Jim Deuchars

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Heart

215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects

White Rose Research Online

This is a repository copy of 215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects.White Rose Research Online URL for this paper:http://eprints.whiterose.ac.uk/111155/Version: Accepted VersionProceedings Paper:Murray, A, Clancy, J, Deuchars, S orcid.org/0000-0002-1876-3239 et al. (1 more author) (2016) 215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects. In: Heart. BCS Annual Conference. ‘Prediction and Prevention’, 06-08 Jun 2016, Manchester Central, UK. BMJ Publishing Group , A142-A142. https://doi.org/10.1136/heartjnl-2016-309890.215© 2016, BMJ Publishing Group Ltd and the British Cardiovascular Society. This is an author produced version of a conference abstract published in Heart. Uploaded in accordance with the publisher's self-archiving policy.eprints@whiterose.ac.ukhttps://eprints.whiterose.ac.uk/Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version - refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher’s website. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects  Aaron Murray, University of Leeds Jennifer Clancy, University of Glasgow Susan Deuchars, University of Leeds Jim Deuchars, University of Leeds   Ageing is associated with autonomic dysfunction and increased risk of chronic cardiovascular disease. The aim of the present study is to assess the effects of a non-invasive method of vagus nerve stimulation, transcutaneous vagus nerve stimulation (tVNS) on autonomic activity in older healthy human subjects aged >60 years.   tVNS was applied to the tragus of both ears in 18 subjects (F=12, M=6). Subjects received either 15 min active tVNS or sham stimulation at two visits while heart rate, blood pressure and respiration were monitored. Heart rate variability was derived from power spectral analysis of beat-to-beat oscillations in heart rate. The LF/HF ratio was calculated using low frequency power and high frequency power. Single-unit muscle sympathetic nerve activity (MSNA) was recorded using microneurography.   12 subjects (M=6) had a significant decrease in LF/HF ratio during active tVNS (1.99 ± 0.24 to 1.25 ± 0.14; p = 0.01). The remaining subjects (F=6) did not experience any changes in LF/HF. Male subjects had a higher baseline LF/HF (M= 2.00 ± 0.16, F= 1.47 ± 0.31; p = 0.01). Low frequency power continued to decrease after active tVNS, with no change in high frequency power. No changes in LF/HF were observed as a result of sham stimulation. Microneurography in 5 subjects detected a decrease in single-unit MSNA frequency and incidence during active tVNS (Z=-2.02; p=0.04).   These results indicate that tVNS reduces MSNA and shifts cardiac autonomic control toward parasympathetic predominance in older adults. Further studies are needed to determine the long-term autonomic effects of tVNS in older subjects.   

215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects

https://eprints.whiterose.ac.uk/111155/1/Heart%20View_abstract_June16.pdf

215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects

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