Is pale the way to go to understand adenomyosis?

Abstract

Adenomyosis (AM) remains one of the unsolved conundrums of gynecology. After decades of debate and numerous studies it is now well accepted that adenomyosis does not represent a sub-entity of endometriosis, although some symptoms appear to overlap. One of the few established facts about AM is the descriptive diagnosis of endometrial glandular epithelial and stromal cells surrounded by hypertrophy and hyperplasia in the myometrial compartment of the uterus (1). Unfortunately, even the most fundamental clinical details including reliable data about the true prevalence, possible familial accumulations or risk factors are sparse and are either based on retrospective studies using hysterectomy specimen or, more recently, on ultrasound or magnetic resonance imaging (MRI) reports without internationally agreed diagnostic standards (2)