Medical image analysis has grown into a matured field challenged by progress made across all medical
imaging technologies and more recent breakthroughs in biological imaging. The cross-fertilisation
between medical image analysis, biomedical imaging physics and technology, and domain knowledge
from medicine and biology has spurred a truly interdisciplinary effort that stretched outside the original
boundaries of the disciplines that gave birth to this field and created stimulating and enriching synergies.
Consideration on how the field has evolved and the experience of the work carried out over the last
15 years in our centre, has led us to envision a future emphasis of medical imaging in Precision Imaging.
Precision Imaging is not a new discipline but rather a distinct emphasis in medical imaging borne
at the cross-roads between, and unifying the efforts behind mechanistic and phenomenological modelbased
imaging. It captures three main directions in the effort to deal with the information deluge in
imaging sciences, and thus achieve wisdom from data, information, and knowledge. Precision Imaging is
finally characterised by being descriptive, predictive and integrative about the imaged object. This paper
provides a brief and personal perspective on how the field has evolved, summarises and formalises our
vision of Precision Imaging for Precision Medicine, and highlights some connections with past research
and current trends in the field
