Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

A.A. Roger Thompson; Alison M. Condliffe; Antonova; Bass; Baudry; Belaaouaj; Berger; Brinkmann; Bruick; Campbell; Cascão; Chacko; Chertov; Colgan; Colotta; Cramer; Dancey; Dyugovskaya; Dyugovskaya; Edwin R. Chilvers; Elks; Elks; Ellson; Eltzschig; Flannagan; Foster; Freischlag; Fritzenwanger; Fuchs; Grahl; Green; Green; Gresham; Haslett; Heit; Herbert; Hoenderdos; Jing; Jonsson; Jung; Katharine M. Lodge; Kinkel; Kiss; Knighton; Knowles; Kobayashi; Kong; Kuijpers; Lakshman; Lando; Leire; Li; Lin; Lone; Lu; Mahnke; Maianski; Mandell; Mani; McGovern; Mcinturff; Menegazzi; Nolte; Okumura; Ong; Pearl-Yafe; Peyssonnaux; Pilsczek; Polosukhin; Pragman; Reeves; Rothfork; Rotstein; Schnyder; Schulz; Serebrovskaya; Simmen; Simms; Spencer; Stewart; Summers; Takashima; Tamura; Tausendschon; Thammavongsa; Thompson; Tohme; Urban; Walmsley; Walmsley; Walmsley; Wang; Werth; Wilde; Wolach; Wood; Yoon; Zheng; Zinkernagel

research

Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Abstract

Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.This work was supported by a Wellcome Trust Research Training Fellowship awarded to K.M.L, Papworth Hospital Research and Development Department and the NIHR Cambridge Biomedical Research Centre