Battisti, Giacomo

Bergamasco, Laura Maria

Bugianesi, Elisabetta

Cannillo, Margherita

Faletti, Riccardo

Frea, S.

Marengo, Andrea

Mezzabotta, Lavinia

Morello, Mara

Mosso, E.

Rizzetto, Mario

Rosso, Chiara

Vanni, Ester

English

Institutional Research Information System University of Turin

RS-3482Fatty liver diseaseClinicalINCREASED EPICARDIAL FAT AND EARLY SIGNS OF IMPAIRED DIASTOLIC AND SYSTOLIC LEFTVENTRICULAR FUNCTION IN NON- DIABETIC, NON-DYSLIPIDEMIC, NORMOTENSIVE PATIENTS WITHNONALCOHOLIC FATTY LIVER DISEASEEster Vanni1, Andrea Marengo* 1, Riccardo Faletti2, Mara Morello3, Lavinia Mezzabotta1, Giacomo Battisti2, Simone Frea3,Margherita Cannillo3, Elena Mosso1, Chiara Rosso1, Laura Bergamasco4, Mario Rizzetto1, Elisabetta Bugianesi11University of Turin, Department of Medical Sciences, Division of Gastroenterology, 2University of Turin, Department ofDiagnostic Imaging and Radiotherapy, Radiology, 3University of Turin, Department of Medical Sciences, Division ofCardiology, 4University of Turin, Turin, ItalyCorresponding author’s email: estervanni@yahoo.itDo you want to apply for a Young Investigator Bursary?: YesBackground and Aims: Nonalcoholic Fatty Liver Disease (NAFLD) has been associated with subclinical cardiovasculardisease (CVD) and increased CVD morbidity and mortality. This study was undertaken to 1) ascertain whether NAFLDpatients have abnormal epicardial fat, left ventricular (LV) morphology and function, 2) determine the relative contributionof epicardial, visceral and hepatic fat to LV dysfunction.Methods: Nineteen non-diabetic, non-dyslipidemic, non-hypertensive patients with biopsy-proven NAFLD (17 men, age41±8 years, BMI 26.8±3kg/m2) and 9 healthy controls (5 men, age 30±2 years, BMI 22.5±2kg/m2) underwenttransthoracic echocardiography and cardiac MRI to quantify epicardial fat and cardiac morphology and function. Anabdomen MRI was performed in all subjects to quantify visceral and hepatic fat.Results: The end-systolic  LV diameter (30.4±3.7 vs 27.2±3.5 mm, p=0.044) and the left atrial area (19.6±3.3 vs 14.9±2.5cm2, p=0.02) were significantly higher in patients than in controls. Indices of LV diastolic function, namely the early diastolic septal and lateral mitral annular velocities, were significantly impaired in NAFLD (9.7±2.6 vs 12.9±2.57 and13.3±3.5 vs 16.4±1.6 cm/s, vs controls respectively; p<0.03 for both). Similarly, the ratio of early to late diastolic mitralinflow (E/A ratio) was significantly reduced in patient than in controls (1.2±0.2 vs 1.5±0.2, p=0.004) suggesting an earlydiastolic dysfunction. Epicardial fat in NAFLD patients was significantly increased compared to controls, both atechocardiography and at MRI (5.93±2.25 vs 0.26±0.5 mm, 228.1±112.8 vs 66.8±25.2cm3, respectively, p=0.001). InNAFLD patients, but not in controls, epicardial fat positively correlated with end-systolic LV diameter (r=0.46, p=0.046)and inversely with the ejection fraction (EF). Epicardial fat was tightly related to visceral fat (r=0.58, p=0.03), but not tohepatic fat. Visceral fat inversely correlated with EF, whereas hepatic fat directly correlated with the end systolic LVvolume (r=0.63, p=0.004).Conclusions: Non diabetic, non-dyslipidemic, normotensive NAFLD patients show early signs of both diastolic andsystolic LV dysfunction. Epicardial, visceral and hepatic fat are increased and associated with parameters of early systolicdysfunction.Funded  by  FP7/2007-2013  under  grant  agreement  n  HEALTH-F2-2009-241762  for  the  project  FLIP  and  by  PRIN2009ARYX4TDisclosure of Interest: None Declared

Increased epicardial fat and early signs of impaired diastolic and systolic left ventricular function in non-diabetic, non-dyslipidemic, normotensive patients with Nonalcoholic Fatty Liver Disease

https://iris.unito.it/bitstream/2318/1570788/1/Abstract%20EASL%202015%20Vanni.pdf

Increased epicardial fat and early signs of impaired diastolic and systolic left ventricular function in non-diabetic, non-dyslipidemic, normotensive patients with Nonalcoholic Fatty Liver Disease

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