Berti, A

Garbarini, F

Gindri, P

Pia, L

Piedimonte, A

Rabuffetti, M

Solito, G

English

Garbarini, Francesca

Pia, Lorenzo

Piedimonte, Alessandro

Berti, Annamaria

Institutional Research Information System University of Turin

Your hand is my hand! Bimanual coupling effect in a somatoparaphrenic patient

152 Cognitive Neuroscience Society — 2012 Annual MeetingPoster Session E — Monday, April 2, 8:00 - 10:00 am, Exhibit HallE95YOUR HAND IS MY HAND! BIMANUAL COUPLING EFFECT IN ASOMATOPARAPHRENIC PATIENT Francesca Garbarini1, L. Pia1, A.Piedimonte1, M. Rabuffetti2, P. Gindri3, A. Berti1; 1University of Turin,2Foundation Don Carlo Gnocchi IRCCS, Milan, 3San Camillo Hospital, Turin —When people are required to draw circles with one hand while drawinglines with the other, both the trajectories tend to become ovals (Franz,2003). Recently, we showed (Garbarini et al. under review) that theseeffects occur in both actual bimanual movements and when an activelimb movement is combined with an illusory limb movement (i.e.,anosognosia for hemiplegia). Those results would support the view thatcoupling effects arises from central signals (e.g., sensory predictions)rather than on actual feedbacks (Franz, 2003). Here we examine whethercoupling effects are present also when an active movement is combinedwith a movement performed by another person’s hand, misidentified asone’s own hand. One right-brain-damaged-patients affected by lefthemiplegia and misidentifications of the experimenter’s hand as his ownhand (somatoparaphrenia), five hemiplegic patients and ten healthy sub-jects were administered a bimanual circle-line drawing task. Participantswere asked to draw lines with the right hand (baseline) and a) to drawcircles with their own left hand b); to draw circles with their own lefthand passively moved; c) to observe the examiner drew circle with hisleft hand positioned in a compatible orientation with respect to the sub-ject’s body. Results showed that, in the crucial c) condition, only in thepatient who misidentified the experimenter’s hand as his own, the linesproduced with the right hand were significantly ovalized in respect tothe baseline (p = 0.0001). These results give interesting new hints regard-ing the link between body ownership and sense of agency.E96FUNCTIONAL ROLE OF PRIMARY MOTOR CORTEX IN MOTOR IMAGERYMEASURED WITH FMRI AND MEG Hana Burianová1, Paul Sowman1, LarsMarstaller1, Graciela Tesan1, Anina Rich1, Mark Williams1, Greg Savage1,Blake Johnson1; 1Macquarie University, Sydney, Australia — Motor imagery(MI) is an internal rehearsal of a movement without any overt physicalaction. Neuroimaging studies have demonstrated that the neural mecha-nisms of MI substantially overlap with the mechanisms of motor execu-tion (ME). Surprisingly, however, the role of primary motor cortex(PMC) remains controversial, as many studies have failed to show con-sistent activations of PMC during MI, a variability that may be largelydue to differences in MI tasks. The objectives of this study were to (1)design a novel task that reliably invokes MI; and (2) compare PMC acti-vations measured with functional magnetic resonance imaging (fMRI)and magnetoencephalography (MEG). Participants heard a sequence ofauditory cues corresponding to the digits of the right or left hand andresponded by raising or lowering the relevant digits, or imagining suchmovements. At the end of each cue sequence, the participants decidedwhether their own digit configuration was the same or different from apicture of a hand displayed on the screen. In all participants, fMRI analy-sis showed PMC activation during MI and ME, and MEG analysisshowed significant beta-band desynchronization in the same PMCregion at a latency of about 500ms from movement or imagery onset.These results demonstrate that our MI task robustly and reliably acti-vated PMC. This paradigm may thus prove useful in clarifying the pre-cise role of PMC in MI, as well as in examining the functional status ofPMC in patients with motor disorders.E97FAVOURITISM IN THE SENSORIMOTOR SYSTEM: HISTORY OFINTERACTION MODULATES SIMULATION OF AN ANTICIPATED ACTIONDimitrios Kourtis1, Natalie Sebanz1, Günther Knoblich2; 1Donders Institute forBrain, Cognition, and Behaviour, Radboud University Netherlands, 2CentralEuropean University, Budapest, Hungary — The ability to anticipate others’actions is crucial for social interaction. We have recently showed that onesimulates in advance an action performed by an interaction partner andpractically ignores the same action performed by a person that (s)henever interacts with (Kourtis et. al., Biology Letters, 2010). In the presentstudy we explored the effects of interaction history on action simulation.The setup comprised of an EEG participant, an interaction partner andan “outsider” (i.e. a person only performing individual actions). The taskof the EEG participant was to plan and perform an individual action (lift-ing an object) or a joint action (giving or receiving an object) or to antici-pate to observe the same individual action performed by either thepartner or the “outsider”. The EEG participant had the role of the giveror the receiver in the 1st half of the experiment and the opposite role inthe 2nd half; moreover, the partner in one half became the “outsider” inthe other half (and vice versa). We recorded stronger mu rhythm (8-12Hz) decrease over sensorimotor cortex before and during the earlystages of the partner’s (individual) action in the 1st half of the experi-ment, but no difference between the partner’s and “outsider’s” actions inthe 2nd half. These findings strengthen the notion that one’s sensorimo-tor system favours the actions of an interaction partner over the sameactions performed by an “outsider”; however, this favouritism disap-pears when the outsider has interacted with the observer in the past.E98INTERLIMB COUPLING DUE TO ILLUSORY MOVEMENTS: EVIDENCEFROM ANOSOGNOSIA FOR HEMIPLEGIA Lorenzo Pia1, FrancescaGarbarini1, Lucia Spinazzola2, Maurizio Ferrarin3, Marco Rabuffetti3,Alessandro Piedimonte1, Jon Driver4, Anna Berti1; 1Psychology Department &Neuroscience Institute of Turin (NIT), Turin, 2Hospital Company ‘S. AntonioAbate’, Gallarate (Milan), 3Bioengeneering Center, Foundation ‘Don CarloGnocchi’ IRCCS, Milan, 4Institute of Cognitive Neuroscience, University Collegeof London, London — In anosognosia for hemiplegia, patients affected by acomplete paresis of the side of the body opposite to the brain lesion mayclaim having performed willed actions with the paralyzed limb despiteunambiguous evidence to the contrary. Does this false belief of beingable to move reflects the functioning of the mechanisms that govern nor-mal motor performance? By examining in anosognosic patients the tem-poral coupling effects known to exist during bimanual movements innormal subjects, we demonstrated that the illusory movements of theplegic arm impose to the healthy arm the same constraints that emergeduring actual movements. Our findings strongly suggest that the sameneurocognitive processes subserving movement execution underpin the‘nonveridical’ experience of willed movements in anosognosic patients.Additionally, these data support the view that coupling effects dependon information already within the brain (i.e., a motor representation),rather than on on-line information from the periphery.E99NEURAL REFLECTIONS OF STATISTICAL STRUCTURE IN OBSERVEDACTIONS Christiane Ahlheim1,2, Waltraud Stadler3,4, Ricarda I. Schubotz1,2;1Max-Planck-Institute for Neurological Research, 2Westfälische Wilhelms-Universität Münster, 3Max-Planck-Institute for Human Cognitive and BrainSciences, 4Technische Universität München — The statistical structure ofour environment can be used to generate predictions of its future states.The present functional magnetic resonance imaging (fMRI) study aimedat exploring the neural reflections of humans’ sensitivity to statisticalstructure in actions. We developed an arbitrary but naturalistic actionsyntax. It consisted of particular transition probabilities (0.25, 0.5, 0.75and 1.0) between six different elements of a construction toy. This setupallowed comparison of the neural effects of observing transitions thatdid to a larger (probabilities 0.75 and 1.0), or smaller extend (probabilityof 0.25) accord to the canonical model. On two successive training days,15 subjects implicitly learnt the syntax by watching clips of actionsequences. During the fMRI on the third day they were exposed to thesame sequences. Activity increased at points of transitions (graspingnew elements versus manipulation of elements) in the posterior middletemporal gyrus, anterior intraparietal sulcus and ventral premotor cor-tex, suggesting an intensified search for memorized action steps or anintensified matching between memorized and perceived manipulationsat the beginning of a new action step. The parametric effect of transition

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Your hand is my hand! Bimanual coupling effect in a somatoparaphrenic patient

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