A new series ofAspirin - thiourea derivatives have been synthesized for biological interest by addition of active amine groups like Para-ansidine, Orto-anisidine, Ortotoluidin and Para-Chloroaniline. The structure of synthesized compound was characterized by IR, IHNMR and IlCNMR. The synthesized compounds were screened for their antibacterial activity using Gram negative bacteria (Ecoli) using Disc diffusion method.2- {[(2methylphenyl)carbamothioyl] carbamoyl) phenyl acetate
showed excellent inhibition against Ecoli compared to all synthesized compound
