Hoback, W.W

Miller, Jon S.

Nor Aliza, AR

Pedibhotla, Venkat K.

Rana, Rico L.

Stanley, D.W.

Unimas Institutional Repository

Comparative Biochemistry and Physiology Part A: Physiology Volume 118, Issue 1, September 1997, Pages 93–100  Eicosanoids Mediate Nodulation Responses to Bacterial Infections in Larvae of the Silkmoth, Bombyx mori David W Stanley-Samuelson , Venkat K Pedibhotla, Rico L Rana, Nor Aliza Abdul Rahim, W.Wyatt Hoback, Jon S Miller  Abstract 1) Nodulation is the first, and qualitatively predominant, cellular defense reaction to bacterial infections in insects and other invertebrates; 2) treating silkworms, Bombyx mori, with the eicosanoid biosynthesis inhibitor, dexamethasone, strongly reduced nodulation responses to bacterial infections; 3) the influence of dexamethasone was reversed by injecting the eicosanoid-precursor polyunsaturated fatty acid, arachidonic acid (20:4n-6), into dexamethasone-treated, infected larvae; 4) the presence of an eicosanoid biosynthesis system in silkworms was documented. Demonstrated elements include a digestive phospholipase A2, incorporation of exogenous 20:4n-6 into fat body phospholipids, the presence of 20:4n-6 in cellular phospholipids, a fat body intracellular phospholipase A2 that can hydrolyze 20:4n-6 from cellular phospolipids, and eicosanoid biosynthetic enzymes; and 5) these findings support the hypothesis that eicosanoids mediate cellular immune responses to bacterial infections in silkworms.  Keywords: Silkmoth; Bombyx mori; insect immunity; nodulation; eicosanoids  

Eicosanoids mediate nodulation responses to bacterial infections in larvae of the silkmoth, Bombyx mori.

http://ir.unimas.my/id/eprint/2234/1/Eicosanoids%20mediate%20nodulation%20responses%20to%20bacterial%20infections%20in%20larvae%20of%20the%20silkmoth%2C%20Bombyx%20mori..pdf

Eicosanoids mediate nodulation responses to bacterial infections in larvae of the silkmoth, Bombyx mori.

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