We investigate the origin of the strong radial gradient in the
ultraviolet-to-infrared ratio in the spiral galaxy NGC 300, and emphasize the
importance of local variations in the interstellar medium geometry, concluding
that they cannot be neglected with respect to metallicity effects. This
analysis is based upon a combination of maps from GALEX and Spitzer, and from
the ground (UBVRI, Halpha and Hbeta). We select ionizing stellar clusters
associated with HII regions of widely varying morphologies, and derive their
fundamental parameters from population synthesis fitting of their spectral
energy distributions, measured to eliminate local backgrounds accurately. From
these fits, we conclude that the stellar extinction law is highly variable in
the line of sight of young clusters of similar ages. In the particular model
geometry that we consider most appropriate to the sampled regions, we checked
that our findings are not significantly altered by the correct treatment of
radiative transfer effects. The variations are systematic in nature: extinction
laws of the Milky Way or LMC type are associated with compact HII regions (the
compacity being quantified in two different ways), while clusters surrounded by
diffuse HII regions follow extinction laws of the 30 Doradus or SMC type. The
Calzetti starburst attenuation law, although most often degenerate with the 30
Doradus extinction law, overpredicts ionizing photon fluxes by large amounts.
We also find that the extinction law variations are correlated with the column
density of dust species emitting in the near- and mid-infrared. Finally, we
briefly discuss the nebular to stellar extinction ratios, and the excitation of
aromatic band carriers, invalidating their claimed association with cold dust.Comment: accepted for publication in ApJ -- figure 6 abridged her