Bigagli, Elisabetta

Biondi, Natascia

Cinci, Lorenzo

Giulia, Mori

Lodovici, Maura

Luceri, Cristina

Mario, D&#8217

Niccolai, Alberto

Rodolfi, Liliana

Tredici, Mario R.

English

Florence Research

See	discussions,	stats,	and	author	profiles	for	this	publication	at:	https://www.researchgate.net/publication/321533135Nutraceutical	properties	of	a	Tisochrysis	luteaenriched	diet:	a	1-month	study	in	ratsConference	Paper	·	December	2017CITATIONS0READS710	authors,	including:Some	of	the	authors	of	this	publication	are	also	working	on	these	related	projects:Development	of	biodegradable	nanocarriers	for	site-specific	delivery	of	natural	molecules	ViewprojectExosomal	miRNAs	and	metastasis:	what	is	the	message?	to	whom	is	it	for?	View	projectMario	TrediciUniversity	of	Florence121	PUBLICATIONS			4,845	CITATIONS			SEE	PROFILENatascia	BiondiUniversity	of	Florence42	PUBLICATIONS			2,348	CITATIONS			SEE	PROFILEMaura	LodoviciUniversity	of	Florence102	PUBLICATIONS			2,799	CITATIONS			SEE	PROFILECristina	LuceriUniversity	of	Florence102	PUBLICATIONS			2,481	CITATIONS			SEE	PROFILEAll	content	following	this	page	was	uploaded	by	Alberto	Niccolai	on	05	December	2017.The	user	has	requested	enhancement	of	the	downloaded	file.         BOOK OF ABSTRACTS  160  Nutraceutical properties of a Tisochrysis lutea enriched diet: a 1-month study in rats    Elisabetta Bigagli1, Lorenzo Cinci1, Alberto Niccolai2, Mario R. Tredici2, Liliana Rodolfi2, Natascia Biondi2, Maura Lodovici1, Mario D’Ambrosio1, Giulia Mori1, Cristina Luceri1  1Department of NEUROFARBA, section of Pharmacology and Toxicology, University of Florence, Italy; 2Department of Agrifood Production and Environmental Sciences (DISPAA), University of Florence, Italy   Abstract: Tisochrysis lutea is a marine microalga, which contains bioactive compounds such as polyunsaturated fatty acids and fucoxanthin. In this 1-month study, the effects of a diet containing 20% T. lutea F&M-M36 were investigated in rats. No adverse effects regarding food consumption, growth or animal behavior were observed, nevertheless rats fed T. lutea showed a tendency to a reduction in body weight gain and a significantly higher water intake compared to controls fed a standard diet (AIN-76). The high Na+ content of the algal biomass induced a huge increase in urinary Na+ and urine production, but blood pressure, creatinine and urea blood levels as well as kidney histopathology were not suggestive of renal impairment. In rats fed the T. lutea diet a significant increase in HDL and decreased plasma triglycerides, with an increased excretion of fecal lipids were observed. These animals showed also a significant increase of PPARγ and UCP-1 and a significant reduction of APOA-1 and LPL hepatic gene expression, compared to controls. These data indicate that a diet supplemented with 20% of T. lutea biomass modulates the expression of genes involved in lipid metabolism, suggesting that this microalga might represent a promising source of functional foods for the prevention of dyslipidemias and associated diseases. However, the high Na+ content of the algal biomass may represent a safety issue, which must be solved before this microalga can be used in humans.    View publication stats

Nutraceutical properties of a Tisochrysis lutea enriched diet: a 1-month study in rats

https://flore.unifi.it/bitstream/2158/1106219/1/d.pdf

Nutraceutical properties of a Tisochrysis lutea enriched diet: a 1-month study in rats

Abstract

Similar works

Full text

Available Versions

Florence Research