Akdogan, B.

Brookman May, S.

Capitanio, U.

Klatte, T.

Langenhuijsen, H.

Marszalek, M.

Minervini, Andrea

Rodriguez Faba, O.

Roscigno, M.

Salagierski, M.

Stewart, G.

Volpe, A.

English

Florence Research

522 Temporal trends in the rate of lymph node dissection for renal cell carcinoma Eur Urol Suppl 2016;15(3);e522          Print!Capitanio U.1, Stewart G.2, Klatte T.3, Volpe A.4, Akdogan B.5, Roscigno M.6, Langenhuijsen H.7, Marszalek M.8, Rodriguez Faba O.9,Salagierski M.10, Minervini A.11, Brookman-May S.121IRCCS Ospedale San Raffaele, Dept. of Urology, Milan, Italy, 2Western General Hospital, Dept. of Urology, Edinburgh, United Kingdom,3Vienna Medical University, Dept. of Urology, Vienna, Austria, 4Maggiore Della Carità Hospital, Dept. of Urology, Novara, Italy, 5HacettepeUniversity, Dept. of Urology, Ankara, Turkey, 6Papa Giovanni XXIII Hospital, Dept. of Urology, Bergamo, Italy, 7Radboud University MedicalCenter, Dept. of Urology, Nijmegen, The Netherlands, 8Donauspital, Dept. of Urology, Vienna, Austria, 9Fundacio-Puigvert, Dept. ofUrology, Barcelona, Spain, 10Kent & Canterbury Hospital, Dept. of Urology, Canterbury, United Kingdom, 11Azienda OspedalieroUniversitaria Careggi, Dept. of Urology, Florence, Italy, 12LMU-Klinikum der Universität München, Dept. of Urology, Munich, GermanyINTRODUCTION & OBJECTIVES: Although randomized prospective data demonstrated no benefit in performing lymph node dissection(LND) at the time of nephrectomy in cN0 disease, some retrospective studies support its use in certain clinical scenarios. Recent reportssuggested underuse of LND in the United States, where today less than 20% of the patients undergo LND at the time of nephrectomy. Weanalysed European trends of LND utilization relying on a large Pan-European collaboration.MATERIAL & METHODS: Using a multi-institutional database, including 15,341 patients with RCC who underwent radical or partialnephrectomy from 1985 to 2014, we analysed changes in LND rates over time according to clinical and pathological characteristics.Descriptive analyses, univariable and multivariable logistic regression analyses were used.RESULTS: Overall, 6,907 patients (45.0%) with cN0 disease received a LND, with major disparities among different countries (range: 17.8-75.0%). Among LND cases, 697 (10.1%) showed lymph node invasion at final pathology. When performed, LND was most of the time notextended and templates were not standardized. LND was performed in 37.8 vs. 61.9 vs. 53.0 vs. 68.7% of T1 vs. T2 vs. T3 vs. T4 cases,respectively (p<0.0001). At multivariable analyses, predictors of LND consisted of patient age (OR 0.98, 95%CI 0.97-0.99, p<0.0001), typeof surgery (partial vs. radical nephrectomy: OR 0.23, 95%CI 0.19-0.27, p<0.0001), surgical approach (laparoscopic vs. open: OR 0.49,95%CI 0.41-0.57, p<0.0001; robotic vs. open: OR 0.44, 95%CI 0.21-0.91, p=0.02), clinical size (OR 1.11, 95%CI 1.08-1.14, p<0.0001), Tstage (p=0.001), and year of surgery (OR 0.96, 95%CI 0.95-0.97, p<0.0001). Indeed, there was a gradual decline in LND beginning in the1990ies that accelerated in 2008 after the publication of the EORTC trial showing no benefit in terms of survival for patients treated withLND. LND rates ranged between 32.0 and 56.2% from 1985 to 2008 vs. 23.4-30.1% after 2008 (p<0.0001). This decline was also driven bystage migration to low stage diseases, use of minimally invasive surgery, and centers’ disparities.CONCLUSIONS: There has been a significant decline in LND rates for kidney cancer over the past years. LND is more frequentlyperformed in younger patients, locally advanced diseases, and open surgery with significant disparities among centers. Although declining,unstandardized and limited in its extension, LND is still more frequently performed in Europe than in the United States.

Temporal trends in the rate of lymph node dissection for renal cell carcinoma

https://flore.unifi.it/bitstream/2158/1056713/1/522-Temporal-trends-in-the-rate-of-lymph-node-dissection-for-renal-cell-carcinoma_2016_European-Urology-Supplements%20-%20Copia.pdf

Temporal trends in the rate of lymph node dissection for renal cell carcinoma

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