Antonelli, A.

Bertolo, R.

Bianchi, G.

Campi, R.

Carini, Marco

Fiori, C.

Giancane, S.

Longo, N.

Mari, A.

Minervini, Andrea

Mirone, V.

Morgia, G.

Novara, G.

Porpiglia, F.

Rocco, B.

Schiavina, R.

Serni, Sergio

Simeone, C.

Sodano, M.

Terrone, C.

English

Florence Research

976 Predictors of overall and new-onset renal function impairment after partial nephrectomy:Results from two-years follow up of a prospective multicentre study (RECORd 1 project) Eur Urol Suppl 2016;15(3);e976          Print!Minervini A.1, Mari A.1, Campi R.1, Novara G.2, Antonelli  A.3, Bertolo R.4, Bianchi G.5, Fiori C.4, Giancane S.1, Longo N.6, Mirone V.6,Morgia G.7, Porpiglia F.4, Schiavina R.8, Serni S.1, Simeone C.3, Sodano M.3, Rocco B.9, Terrone C.10, Carini M.11University of Florence, Dept. of Urology, Florence, Italy, 2University of Padua, Dept. of Urology, Padua, Italy, 3Spedali Civili, Dept. ofNephroUrology, Brescia, Italy, 4University of Turin, S.Luigi Gonzaga Hospital, Dept. of Urology, Turin, Italy, 5University of Modena, Dept. ofUrology, Modena, Italy, 6University of Naples, Federico II, Dept. of Urology, Naples, Italy, 7Luna Foundation, -, Italy, 8University of Bologna,S. Orsola-Malpighi Hospital, Dept. of Urology, Bologna, Italy, 9University of Milan, IRCCS Ca' Granda Hospital, Dept. of Urology, Milan,Italy, 10A.O. Maggiore Della Carità Hospital, Dept. of Urology, Novara, ItalyINTRODUCTION & OBJECTIVES: The aim of the study was to analyse renal functional outcomes after partial nephrectomy (PN) and tosearch for predictive factors of chronic kidney disease (CKD) impairment in a multicenter prospective observational study (RECORdProject).MATERIAL & METHODS: Overall, 1055 patients treated with PN for cortical renal tumors were prospectively recorded from 2009 to 2012. A24-months functional follow-up was recorded in 709 patients. A uni- and multivariable logistic regression analysis for overall and new-onsetCKD impairment (stage migration) were performed.RESULTS: Median eGFR was 84.5 (69.9-99.1) ml/min/1.73m2. According to eGFR, CKD was stage 1 in 275 (38.8%), stage 2 was 341(48.2%), stage ≥3 was in 92 (12.9%) patients. Open, laparoscopic and robot-assisted PN was performed in 335 (47.3%), 259 (36,6%), 114(16.1%) cases. Pedicle clamping was performed in 62.4% of cases. Median warm ischemia time (WIT) was 17 (IQR: 13-22) minutes.Median delta eGFR at 3rd, 30th POD was 10.2 (0-23.3) and 8.4 (0-21.2) ml/min/1.73m2. Overall and new-onset CKD impairment wasrecorded in 205 (28.9%) and 125 (45.5%) patients.At multivariable analysis, females (OR 2.82, CI 1.66-4.80, p<0.0001), ECOG score ≥1 (OR 2.49, CI 16-4.0, p=0,004), higher preoperativeeGFR (OR1.02, IC95% 1.01-1.03p<0,0001) were significant predictive factors of overall CKD impairment, while females (OR 4.79, CI 2.29-10.02, p<0,0001), ECOG score ≥1 (OR 2.80, CI 1.35-5.80, p=0,006), lower preoperative eGFR (OR 0.98, CI 0.95-1.00, p=0.02),  opensurgical approach (OR2.76, CI 1.12-6.77 p=0.03) and WIT (OR 0.96,  IC 95% 1.00-1.00 p 0.03) were significant predictors of new-onsetCKD impairment.CONCLUSIONS: Open surgical approach, gender and performance status are significant predictive factors of overall and new-onset CKDimpairment. Higher preoperative eGFR showed to be a significant predictive factor for stage migration in the entire cohort due to asignificant proportion of CKD stage1 patients closed to the CKD stage2 threshold limit value and, indeed, it turned to be protective in thesub group of patients with CKD stage1. Minutes of WIT seem to be significantly associated with CKD impairment just in patients with apreserved renal function. Further analyses will focus on absolute and % eGFR impairment of the entire series.

Predictors of overall and new-onset renal function impairment after partial nephrectomy:

Results from two-years follow up of a prospective multicentre study (RECORd 1 project)

https://flore.unifi.it/bitstream/2158/1056743/1/976-Predictors-of-overall-and-new-onset-renal-function-impairment-after-partial-nephrectomy-Results-from-two-years-follow-up-of-a-prospective-multicen.pdf

Predictors of overall and new-onset renal function impairment after partial nephrectomy: Results from two-years follow up of a prospective multicentre study (RECORd 1 project)

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