Objectives: The long-term risks associated with the use of short-term prescription opioids in opioid naïve adolescents in not well characterized. The purpose of this study was to explore the potential association between the days’ supply of the initial prescription opioid exposure and the rates of diagnosed OUD in the subsequent 3-year period. Methods: We conducted a retrospective cohort study using a nationwide database of commercially-insured adolescents aged 12-17 at the time of the index opioid fill. A multivariable Cox Proportional Hazard regression model was developed to analyze the association of interest while accounting for known risk factors for the development of OUD. Results: Results of the Cox Proportional Hazard analysis showed no significant differences in the risks of future OUD diagnosis between any of the days’ supply groups. Conclusions: In this commercially-insured, opioid naïve adolescent population, there was no significant association between the days’ supply of the initial opioid prescription the rate of OUD diagnosis in the subsequent 3-year period
