This policy brief of the European Union (EU) Think Tank – part of the FIT4FOOD2030 Coordination and Support Action (CSA) of the FOOD 2030 initiative – is a response and contribution to growing pleas for a ‘systems approach’ to transform food systems for Food and Nutrition Security (FNS) for present and future generations. This policy brief specifically focusses on the necessity of the adoption of a systems approach to Research and Innovation (R&I) in order to foster the transformation of food systems