The INTEGRAL satellite was launched on October 17, 2002. All on-board
instruments are operating successfully. In this paper, we focus on radiation
effects on the Cadmium Telluride camera ISGRI. The spectral response of the
camera is affected by cosmic particles depositing huge amount of energy,
greater than the high threshold of the electronics. Our study raises the
contribution of cosmic ray protons. Solutions are proposed to limit the
degradation of spectral response of large pixel gamma cameras operating in
space