Medicinal herbs are widely used because of low side effects, recommendation of related industries for cultivation of medicinal plants, preventing the outflow of currency, and particularly the suggestion of world Health Organization to use medicinal herbs. On the other hand, due to lack of an effective medicine for wound healing studying the effects of medicinal herbs on wound healing is essential. Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, poor final cosmetic appearance and the formation of a fragile epithelia

Abdul Jabbar, Omar

Abdul Rahim, Roslina

Kashmola, Muhanad Ali Hamdon

La, Qouta

Mokhtar@Makhtar, Khairani Idah

Muhammad, Siti Aeshah @ Naznin

Mustafa Al-Ahmad, Basma Ezzat

English

Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, a poor final cosmetic appearance and the formation of a fragile epithelial layer. The objective of this study is to evaluate the effectiveness of flaxseed gel in enhancing connective tissue firmness and improving skin texture during wound healing by means of viscoelasticity parameter. 30-male white neozealand rabbit were included in this study divided into 3 groups; one group of 10 rabbit received Flax seed gel topically for three times intervals (1, 3, and 7 days); a second group received Fucidin cream as positive control, while third group have not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system (Cortex Technology). Photos of treated areas were taken during the procedure. Throughout the study skin elasticity was significantly greater in the Flaxseed group than in other groups. Flaxseed increase elasticity value from (4.2±1.02) to (4.7±1.9) after 7 days  treatment (P=0.003). while no significant differences were evident  in both Fucidin treated group (positive) control (1.0±0.34) and non-treated group (negative) control (1.8±1.4) (p=0.068) group. Hence, Young's modulus of skin elasticity in flaxseed group was more reproducible than other groups demonstrating the comparable efficacy of flaxseed extract in skin elasticity and distensibility. This study showed clearly the therapeutic effect of flaxseed extract on biologic tissue, including stimulation of microcirculation and improvement of fibroblastic cell activity. Elasticity evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process

Abdul Qader, Omar Abdul Jabbar

The International Islamic University Malaysia Repository

AJMB, Official Journal of Faculty of Medicine, Universiti Sultan Zainal Abidin, Malaysia. Muhammad et al.                   The effect of flaxseed extract on skin elasticity of the healing wound in rabbit  Omar Abdul Jabbar, Basma Ezzat Mustafa, Muhanad Ali Kashmoola, Khairani Idah Binti Mokhtar, Siti Aesah Naznin Muhammad and Roslina Binti Abdul Rahim  Kulliyyah of Dentistry, IIUM Kuantan Campus, Pahang   drbasma@iium.edu.my   Abstract    Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, a poor final cosmetic appearance and the formation of a fragile epithelial layer. The objective of this study is to evaluate the effectiveness of flaxseed gel in enhancing connective tissue firmness and improving skin texture during wound healing by means of viscoelasticity parameter. 30-male white neozealand rabbit were included in this study divided into 3 groups; one group of 10 rabbit received Flax seed gel topically for three times intervals (1, 3, and 7 days); a second group received Fucidin cream as positive control, while third group have not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system (Cortex Technology). Photos of treated areas were taken during the procedure. Throughout the study skin elasticity was significantly greater in the Flaxseed group than in other groups. Flaxseed increase elasticity value from (4.2±1.02) to (4.7±1.9) after 7 days  treatment (P=0.003). while no significant differences were evident  in both Fucidin treated group (positive) control (1.0±0.34) and non-treated group (negative) control (1.8±1.4) (p=0.068) group. Hence, Young's modulus of skin elasticity in flaxseed group was more reproducible than other groups demonstrating the comparable efficacy of flaxseed extract in skin elasticity and distensibility. This study showed clearly the therapeutic effect of flaxseed extract on biologic tissue, including stimulation of microcirculation and improvement of fibroblastic cell activity. Elasticity evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process.    Keywords: Flaxseed; elasticity; skin wound  *Author for Correspondence                               OP-23 

The effect of flaxseed extract on skin elasticity of the healing wound in rabbit

Introduction: Management of disturbed wounds, large skin defects and the areas where skin tension

precludes wound closure is of high clinical importance. Healing in wounds occurs through epithelization and

contraction processes (second-intentions healing) that may result in certain undesirable complications

including keloid and formation of a fragile epithelial layer. Materials and methods: 27 white New Zealand

rabbit included in this study divided into 3 groups; one group of 9 rabbits received Flaxseed gel topically for

three time intervals (1, 7, and 14 days); a second group received Fucidin cream as positive control, while a

third group has not received any treatment as negative control, Skin elasticity measurements were

performed using the DermaLab system. Results: Throughout the study, skin elasticity was significantly

greater in Flaxseed group than in others. Flaxseed decrease elasticity value from (3.46 ± 2.05). Hence,

Young's modulus of skin elasticity in flaxseed group was (2.46 ± 1.02) after 14 days (p = 0.003), while no

significant differences were evident in both Fucidin group (1.16 ± 0.77) and non-treated group (1.86 ± 1.40)

(p = 0.019), accordingly flaxseed extract more reproducible than other groups demonstrating comparable

efficacy in skin elasticity and distensibility. Conclusions: This study showed the therapeutic effect of

flaxseed on biologic tissue. Elasticity evaluation demonstrated increased density and firmness in the network

of collagen fibers in the dermis and subcutis during wound healing process promise in generating therapeutic

gel to be used in wound healing process

ScopusDocument details 1 of 1The effect  of flaxseed  extract  on skin  elasticity  of the healing  wound  in  rabbits (Article),  ,  ,  ,  ,  ,   Department of Oral Maxillofacial Surgery and Oral Diagnosis, Kulliyyah of Dentistry, International Islamic UniversityMalaysia, MalaysiaFundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, MalaysiaDepartment of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University Malaysia,MalaysiaAbstractIntroduction: Management of disturbed wounds, large skin  defects and the areas where skin  tension precludes wound  closure is of high clinical importance. Healing  in  wounds occurs through epithelization and contractionprocesses (second-intentions healing ) that may result in  certain undesirable complications including keloid andformation of a fragile epithelial layer. Materials and methods: 27 white New Zealand rabbit  included in  this studydivided into 3 groups; one group of 9 rabbits  received Flaxseed  gel topically for three time intervals (1, 7, and 14days); a second group received Fucidin cream as positive control, while a third group has not received any treatmentas negative control, Skin  elasticity  measurements were performed using the DermaLab system. Results:Throughout the study, skin  elasticity  was significantly greater in  Flaxseed  group than in  others. Flaxseeddecrease elasticity  value from (3.46 ± 2.05). Hence, Young's modulus of skin  elasticity  in  flaxseed  group was(2.46 ± 1.02) after 14 days (p = 0.003), while no significant differences were evident in  both Fucidin group (1.16 ±0.77) and non-treated group (1.86 ± 1.40) (p = 0.019), accordingly flaxseed  extract  more reproducible than othergroups demonstrating comparable efficacy in  skin  elasticity  and distensibility. Conclusions: This study showedthe therapeutic effect  of flaxseed  on biologic tissue. Elasticity  evaluation demonstrated increased density andfirmness in  the network of collagen fibers in  the dermis and subcutis during wound  healing  process promise in  generating therapeutic gel to be used in  wound  healing  process. © 2019 Default.SciVal Topic Prominence Topic: Prominence percentile: 95.235   Author keywordsElasticity Flaxseed Rabbit Skin Wound◅ Back to results Export  Download  Print  E-mail  Save to PDF ⋆ Add to List  ▻More...Open AccessInternational Medical Journal MalaysiaVolume 18, Issue 1, 1 March 2019, Pages 5-12Abdul Jabbar, O.a Kashmoola, M.A.a Al-Ahmad, B.E.M.b  Mokhtar, K.I.b Muhammad, N.cAbdul Rahim, R.d Qouta, L.A.e abc  View additional affiliations View references (22)Keloid | Cicatrix | Keloid scarsChemistry database information Substances⤢OOOOOCH3H3CCH3⤢CH 3CH 3CH 3HOOCH 3OOOH 3CHOCH 3H 3CHHHNaPlumX MetricsUsage, Captures, Mentions,Social Media and Citationsbeyond Scopus.Metrics 0 Citations in Scopus0 Field-WeightedCitation ImpactCited by 0 documentsInform me when this documentis cited in Scopus: Related documents,  ,(2014) Technology in CancerResearch and Treatment,  , (2009) Medical Physics,  , (2008) Proc. 5th Int. Workshopon Wearable and ImplantableBody Sensor Networks,Set citation alert ▻ ▻Set citation feedSkin elasticity as a measure ofradiation fibrosis: Is itreproducible and does it correlatewith patient and physician-reported measures? Nguyen, N.-T.A. Roberge, D.Freeman, C.R.Implementation and validation ofan ultrasonic tissuecharacterization technique forquantitative assessment ofnormal-tissue toxicity inradiation therapy Zhou, J. Zhang, P. Osterman,K.S.An OCT-based air jet indentationsystem for the measurement ofmechanical properties of softtissues Huang, Y.P. Zheng, Y.P. Wang,S.Z.References (22)Funding detailsFunding sponsor Funding number AcronymInternational Islamic University MalaysiaFoundation for Fundamental Research on Matter FRGS16-010-0509Funding textThis study was financially supported by the Fundamental Research Grant Scheme (FRGS) Phase 1/2016 (Project ID:FRGS16-010-0509). All the authors would like to thank International Islamic University Malaysia for this financialassistance.Christ, C., Brenke, R., Sattler, G., Siems, W., Novak, P., Daser, A.  (Open Access)(2008) Aesthetic Surgery Journal, 28 (5), pp. 538-544.  . doi: 10.1016/j.asj.2008.07.011 Vercelli, S., Ferriero, G., Sartorio, F., Stissi, V., Franchignoni, F. (2009) Disability and Rehabilitation, 31 (25), pp. 2055-2063.  . doi: 10.3109/09638280902874196aAnthonissen, M., Daly, D., Fieuws, S., Massagé, P., Van Brussel, M., Vranckx, J., Van Den Kerckhove, E. (2013) Burns, 39 (3), pp. 420-428.  . doi: 10.1016/j.burns.2012.07.026 Czaika, V., Alborova, A., Richter, H., Sterry, W., Vergou, T., Antoniou, C., Lademann, J., (...), Koch, S. (2012) Skin Pharmacology and Physiology, 25 (1), pp. 39-46.  . doi: 10.1159/000330486Szyszkowska, B., Łepecka-Klusek, C., Kozłowicz, K., Jazienicka, I., Krasowska, D. ISSN: 18234631Source Type: JournalOriginal language: EnglishDocument Type: ArticlePublisher: International Islamic University Malaysia ▻View in search results format     All Export  Print  E-mail  Save to PDF Create bibliography1Improvement in Skin Elasticity in the Treatment of Cellulite and Connective TissueWeakness by Means of Extracorporeal Pulse Activation TherapyCited 44 timesView at Publisher2How to assess postsurgical scars: A review of outcome measuresCited 84 timesView at Publisher3Measurement of elasticity and transepidermal water loss rate of burn scars with theDermalab®Cited 18 timesView at Publisher4Comparison of transepidermal water loss and laser scanning microscopymeasurements to assess their value in the characterization of cutaneous barrierdefectsCited 16 timesView at PublisherThe influence of selected ingredients of dietary supplements on skin conditionBody Sensor Networks,BSN2008, in conjunction withthe 5th Int. Summer School andSymp. on Medical Devices andBiosensors, ISSS-MDBS 2008 Find more related documents inScopus based on:View all related documents basedon references ▻Authors  ▻KeywordsSzyszkowska, B., Łepecka-Klusek, C., Kozłowicz, K., Jazienicka, I., Krasowska, D. (Open Access)(2014) Postepy Dermatologii i Alergologii, 31 (3), pp. 174-181.  .  doi: 10.5114/pdia.2014.40919Rossi, R., Pastorelli, G., Cannata, S., Corino, C. (2010) Animal Feed Science and Technology, 162 (1-2), pp. 1-11.  . doi: 10.1016/j.anifeedsci.2010.08.013 Bignotti, A.(2014) Intramammary administration of oxygen/ozone mix in oil vehicle blended platelet concentrate as anunconventional therapy in bovine mastitisFirst clinical application. (Universitadegli Studi di Milano) Patel, M.B., Mishra, S.M.(2012) Journal of Functional Foods, 4 (1), pp. 79-86.  . doi: 10.1016/j.jff.2011.08.002 Shim, Y.Y., Gui, B., Arnison, P.G., Wang, Y., Reaney, M.J.T.  (Open Access)(2014) Trends in Food Science and Technology, 38 (1), pp. 5-20.  .  doi: 10.1016/j.tifs.2014.03.011 Trostrup, H., Thomsen, K., Calum, H., Hoiby, N., Moser, C.Animal models of chronic wound care: the application of biofilms in clinical research(2016) CHRONIC WOUND CARE Manag. Res, 3, pp. 123-132.  .  Rahman, M.N.A., Sukmasari, S., Doolaanea, A.A., Qader, O.A.J.A. (2018) Journal of Pharmaceutical Sciences and Research, 10 (1), pp. 167-174.  Davis, A.M., Dische, S., Gerber, L., Saunders, M., Leung, S.F., O'Sullivan, B. (2003) Seminars in Radiation Oncology, 13 (3), pp. 203-213.  .  doi: 10.1016/S1053-4296(03)00022-55 The influence of selected ingredients of dietary supplements on skin conditionCited 7 timeshttp://www.termedia.pl/Journal/-7/pdf-22325-10?filename=The%20influence%20of%20selected.pdfView at Publisher6Recent advances in the use of fatty acids as supplements in pig diets: A reviewCited 45 timesView at Publisher78Magnoflorine from Tinospora cordifolia stem inhibits α-glucosidase and isantiglycemic in ratsCited 37 timesView at Publisher9Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature:AreviewCited 87 timeshttp://www.elsevier.com/wps/find/journaldescription.cws_home/601278/description#descriptionView at Publisher10Cited 6 times11Potential oral wound healing of topical application of dental gel prepared fromBaccaurea angulata fruit in diabetic ratshttp://www.jpsr.pharmainfo.in/Documents/Volumes/vol10Issue01/jpsr10011836.pdf12Measuring postirradiation subcutaneous soft-tissue fibrosis: State-of-the-art andfuture directionsCited 27 timeshttp://www.elsevier.com/inca/publications/store/6/2/3/3/8/0/index.httView at PublisherEpstein, L.B., Graham, C.A., Heit, M.H.(2007) American Journal of Obstetrics and Gynecology, 197 (2), pp. 165.e1-165.e6.  .  doi: 10.1016/j.ajog.2007.03.040 Sutradhar, A., Miller, M.J. (2013) Skin Research and Technology, 19 (1), pp. e191-e199.  . doi: 10.1111/j.1600-0846.2012.00627.x Leung, S.-F., Zheng, Y., Choi, C.Y.K., Mak, S.S.S., Chiu, S.K.W., Zee, B., Mak, A.F.T. (2002) Cancer, 95 (3), pp. 656-662.  . doi: 10.1002/cncr.10700 Huang, Y.P., Zheng, Y.P., Leung, S.F., Choi, A.P.C. High Frequency Ultrasound Assessment of Skin Fibrosis(2007) Clinical Results. Ultrasound Med. Biol, p. 33.  Davis, A.M., Gerrand, C., Griffin, A., O'Sullivan, B., Hill, R.P., Wunder, J.S., Abudu, A., (...), Bell, R.S. (2004) International Journal of Radiation Oncology Biology Physics, 60 (1), pp. 286-294.  . doi: 10.1016/j.ijrobp.2004.02.042 Greaves, N.S., Iqbal, S.A., Hodgkinson, T., Morris, J., Benatar, B., Alonso-Rasgado, T., Baguneid,M., (...), Bayat, A. (Open Access)(2015) Wound Repair and Regeneration, 23 (4), pp. 483-494.  .  doi: 10.1111/wrr.12308 Crichton, M.L., Donose, B.C., Chen, X., Raphael, A.P., Huang, H., Kendall, M.A.F. (2011) Biomaterials, 32 (20), pp. 4670-4681.  . doi: 10.1016/j.biomaterials.2011.03.012 Chen, C.-C., Murray, P.J., Jiang, T.X., Plikus, M.V., Chang, Y.-T., Lee, O.K., Widelitz, R.B., (...), Chuong, C.-M. View at Publisher13Systemic and vaginal biomechanical properties of women with normal vaginal supportand pelvic organ prolapseCited 34 timeshttp://www.elsevier.com/inca/publications/store/6/2/3/2/7/7/index.httView at Publisher14In vivo measurement of breast skin elasticity and breast skin thicknessCited 21 timesView at Publisher15Quantitative measurement of post-irradiation neck fibrosis based on the youngmodulus: Description of a new method and clinical resultsCited 41 timesView at Publisher1617Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosisCited 6 timesView at Publisher18Skin substitute-assisted repair shows reduced dermal fibrosis in acute human woundsvalidated simultaneously by histology and optical coherence tomographyCited 17 timeshttp://www.wiley.com/bw/journal.asp?ref=1067-1927&site=1View at Publisher19The viscoelastic, hyperelastic and scale dependent behaviour of freshly excisedindividual skin layersCited 87 timesView at Publisher20Regenerative hair waves in aging mice and extra-follicular modulators follistatin, Dkk1, 1 of 1 (Open Access)(2014) Journal of Investigative Dermatology, 134 (8), pp. 2086-2096.  .  doi: 10.1038/jid.2014.139Corr, D.T., Gallant-Behm, C.L., Shrive, N.G., Hart, D.A. (2009) Wound Repair and Regeneration, 17 (2), pp. 250-259.  . doi: 10.1111/j.1524-475X.2009.00463.x (2013) (UON). Comparative Skin Morphology and Wound Healing in Kenyan African Mole Rat (TachyoryctesIbeanus) and Naked Mole Rat( Heterocephalus Glaber). (University of Nairobi)  Al-Ahmad, B.E.M.; Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International IslamicUniversity Malaysia, Kuantan, Pahang, Malaysia; email:   © Copyright 2019 Elsevier B.V., All rights reserved.Regenerative hair waves in aging mice and extra-follicular modulators follistatin, Dkk1,and Sfrp4Cited 35 timeshttp://www.nature.com/jid/index.htmlView at Publisher21Biomechanical behavior of scar tissue and uninjured skin in a porcine modelCited 50 timesView at Publisher22 drbasma@iium.edu.my◅ Back to results  Top of pageAbout ScopusWhat is ScopusContent coverageScopus blogScopus APIPrivacy mattersLanguage日本語に切り替える切换到简体中文切換到繁體中文Русский языкCustomer ServiceHelpContact us Copyright © . 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The effect of flaxseed extract on skin elasticity of

the healing wound in rabbits