Paracetamol may be used as an antipyretic agent for the treatment of fever, as well as an analgesic in the treatment of mild to moderate pain post-vaccination in infants. The use of paracetamol during fever may be or may not be recommended since it may alter the natural human body immune response, although it may reduce pain

Draman, Samsul

Mohd Rus, Razman

Mohd Taib, Mai Nurul Ashikin

Shamsudin, Siti Hadijah

Suleiman, Nurain

English

Nurain Suleiman

Siti Hadijah Shamsudin

Razman Mohd Rus

Samsul Draman

Mai Taib

Crossref

Pharmacy

The Relevancy of paracetamol and Breastfeeding Post Infant Vaccination: A Systematic Review

Background: Paracetamol may be used as an antipyretic agent for the treatment of fever, as well as an analgesic in the treatment of mild to moderate pain post-vaccination in infants. The use of paracetamol during fever may be or may not be recommended since it may alter the natural human body immune response, although it may reduce fever and fussiness. Objectives: The aims of this study are to describe the effectiveness of breastfeeding in reducing pain and paracetamol in reducing fever and pain post infant vaccination. Methods: Data sources and study selection was conducted by electronic searching of six databases. Manual reference checks of all articles on paracetamol and breastfeeding post infant vaccination published in the English language between 1978 and 2017. Two levels of screening were used on 9614 citations, which include screening of abstracts and titles followed by full text screening. The data synthesis were tabulated into study characteristics, quality, and effects. Results: Systematic review of breastfeeding included three studies from 9614 database searches found significant benefit from breastfeeding in pain scores and the duration of crying, as well as behavioural changes. None of the studies stated the detriment of breastfeeding before, during, and after immunization. Systematic review of paracetamol effectiveness included four studies from 1177 database searches found significant benefit from prophylaxis paracetamol in fever, one study found significant benefit from prophylaxis paracetamol in fussiness, and one study’s results were found to be not significant. Two studies on evaluating the safety of prophylactic paracetamol in 2009 found that antibody responses to several antigens were significantly reduced, and the other study in 1988 found that antibody titres to DTP bacteria of placebo and PCM did not differ significantly. Conclusions: The relevancy of giving paracetamol post all types of vaccination may be questionable. Breastfeeding before, during, and after immunization are recommended for pain reduction and are proven effective. Further research is required in deciding if paracetamol is to be of rational use following infant immunization

Mai Nurul Ashikin Taib

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1/22/2019 Web of Science [v.5.31] - Web of Science Core Collection Full Recordhttp://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=494&SID=D5lr26D44HRRckieQrV&page=1&doc=1 1/3Web of ScienceThe Relevancy of Paracetamol and Breastfeeding Post Infant Vaccination: ASystematic ReviewBy: Suleiman, N (Suleiman, Nurain)[ 1,2 ] ; Shamsudin, SH (Shamsudin, Siti Hadijah)[ 2 ] ; Rus, RM (Rus, Razman Mohd)[ 3 ] ;Draman, S (Draman, Samsul)[ 3 ] ; Taib, MNA (Taib, Mai Nurul Ashikin)[ 4 ]PHARMACYVolume:  6  Issue:  2Article Number:  27DOI:  10.3390/pharmacy6020027Published:  JUN 2018Document Type: ReviewAbstractBackground: Paracetamol may be used as an antipyretic agent for the treatment of fever, as well as an analgesic in thetreatment of mild to moderate pain post-vaccination in infants. The use of paracetamol during fever may be or may not berecommended since it may alter the natural human body immune response, although it may reduce fever and fussiness.Objectives: The aims of this study are to describe the effectiveness of breastfeeding in reducing pain and paracetamol inreducing fever and pain post infant vaccination. Methods: Data sources and study selection was conducted by electronicsearching of six databases. Manual reference checks of all articles on paracetamol and breastfeeding post infant vaccinationpublished in the English language between 1978 and 2017. Two levels of screening were used on 9614 citations, whichinclude screening of abstracts and titles followed by full text screening. The data synthesis were tabulated into studycharacteristics, quality, and effects. Results: Systematic review of breastfeeding included three studies from 9614 databasesearches found significant benefit from breastfeeding in pain scores and the duration of crying, as well as behaviouralchanges. None of the studies stated the detriment of breastfeeding before, during, and a er immunization. Systematicreview of paracetamol effectiveness included four studies from 1177 database searches found significant benefit fromprophylaxis paracetamol in fever, one study found significant benefit from prophylaxis paracetamol in fussiness, and onestudy's results were found to be not significant. Two studies on evaluating the safety of prophylactic paracetamol in 2009found that antibody responses to several antigens were significantly reduced, and the other study in 1988 found thatantibody titres to DTP bacteria of placebo and PCM did not differ significantly. Conclusions: The relevancy of givingparacetamol post all types of vaccination may be questionable. Breastfeeding before, during, and a er immunization arerecommended for pain reduction and are proven effective. Further research is required in deciding if paracetamol is to be ofrational use following infant immunization.KeywordsAuthor Keywords: paracetamol; breastfeeding; post; childhood; prophylactic; immunization; vaccinationAuthor InformationReprint Address: Suleiman, N (reprint author)       Johor State Hlth Dept, Pharmaceut Serv Div, Johor Baharu 81200, Johor, Malaysia.Reprint Address: Suleiman, N (reprint author)Int Islamic Univ Malaysia, Kulliyyah Pharm, Kuantan 25710, Pahang, Malaysia.Addresses:       [ 1 ] Johor State Hlth Dept, Pharmaceut Serv Div, Johor Baharu 81200, Johor, Malaysia[ 2 ] Int Islamic Univ Malaysia, Kulliyyah Pharm, Kuantan 25710, Pahang, Malaysia[ 3 ] Int Islamic Univ Malaysia, Kulliyyah Med, Kuantan 25710, Pahang, Malaysia       [ 4 ] Ara Damansara Med Ctr, Shah Alam 40150, Selangor, MalaysiaE-mail Addresses: nurain.suleiman@moh.gov.my; shadijah@iiumedu.my; razman@iium.edu.my; nurin@iium.edu.my;dr.mai.nurulashikin@ramsaysimedarbyhealth.comFundingFunding Agency Grant NumberI i l I l i U i i M l i K CCitation NetworkIn Web of Science Core Collection0Times CitedCreate Citation Alert18 Cited ReferencesView Related RecordsUse in Web of ScienceWeb of Science Usage Count1 1 Last 180 Days Since 2013This record is from:Web of Science Core Collection- Emerging Sources Citation Index Suggest a correctionIf you would like to improve the quality ofthe data in this record, please suggest acorrection.Web of Science InCites Journal Citation Reports Essential Science Indicators EndNote Publons Kopernio Sign In  Help  English Tools  Searches and alerts  Search History Marked ListFree Full Text from Publisher   Add to Marked ListFull Text Options  Save to EndNote online  1  of  1 Learn moreSearch Search Results1/22/2019 Web of Science [v.5.31] - Web of Science Core Collection Full Recordhttp://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=494&SID=D5lr26D44HRRckieQrV&page=1&doc=1 2/3(from Web of Science Core Collection)International Islamic University Malaysia, Kuantan Campus   View funding text    PublisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDCategories / ClassificationResearch Areas: Pharmacology & PharmacyWeb of Science Categories: Pharmacology & PharmacySee more data fields  1  of  1 Cited References: 18Showing 18 of 18 View All in Cited References pageTitle: [not available]Group Author(s): American Pharmacists AssociationDRUG INFORM HDB  Published: 2006Publisher: Lexi-comp, Hudson, OH, USATimes Cited: 1  Title: [not available]Group Author(s): Bahagian Pembangunan Kesihatan KeluargaPanduan Program Imunisasi Kebangsaan Kanak-Kanak Untuk Anggota Kejururawatan  Published: 2008Publisher: Kementerian Kesihatan, Kuala Lumpur, MalaysiaTimes Cited: 1  Title: [not available]Group Author(s): Centre for Clinical Practice at NICEFeverish Illness in Children Assessment and Initial Management in Children Younger Than 5 Years  Published: 2013Publisher: National Institute for Health and Care Excellence, Manchester, UKTimes Cited: 1  Title: [not available]Group Author(s): College of PaediatricsMalaysian Immunization Manual  Published: 2001Publisher: Academy of Medicine Malaysia, Kuala Lumpur, MalaysiaTimes Cited: 1  A systematic review of postgraduate teaching in evidence-based medicine and critical appraisalBy: Coomarasamy, A; Taylor, R; Khan, KSMEDICAL TEACHER  Volume: 25   Issue: 1   Pages: 77-81   Published: JAN 2003Times Cited: 55  Title: [not available]By: Cooper, C.; Atkinson, E.J.; O'fallon, W.M.; et al.Incidence of Clinically Diagnosed Vertebral Fractures: A Population-Based Study in Rochester, Minnesota, 1985-1989  Published: 1992Publisher: Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA[Show additional data]Times Cited: 1  The Effect of Prophylactic Antipyretic Administration on Post-Vaccination Adverse Reactions and Antibody Response in Children:A Systematic Review Associated DataBy: Das, Rashmi Ranjan; Panigrahi, Inusha; Naik, Sushree SamikshaPLOS ONE  Volume: 9   Issue: 9     Article Number: e106629   Published: SEP 2 2014Times Cited: 12  SEIZURES FOLLOWING CHILDHOOD IMMUNIZATIONSBy: HIRTZ, DG; NELSON, KB; ELLENBERG, JHJOURNAL OF PEDIATRICS  Volume: 102   Issue: 1   Pages: 14-18   Published: 1983Times Cited: 60  A Randomized Placebo-Controlled Trial of Acetaminophen for Prevention of Post-Vaccination Fever in InfantsTimes Cited: 13  1.2.3.4.5.6.7.8.9.1/22/2019 Web of Science [v.5.31] - Web of Science Core Collection Full Recordhttp://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=494&SID=D5lr26D44HRRckieQrV&page=1&doc=1 3/3 Associated DataBy: Jackson, Lisa A.; Peterson, Do; Dunn, John; et al.PLOS ONE  Volume: 6   Issue: 6     Article Number: e20102   Published: JUN 17 2011Title: [not available]By: Janice, E; Sullivan, M.D; Henry, C.; et al.Group Author(s): the Section on Clinical Pharmacology and Therapeutics, and Committee on DrugsClinical Report: Fever and Antipyretic Use in Children  Published: 2011Publisher: American Academy of Peadiatrics, Itasca, IL, USA[Show additional data]Times Cited: 1  Title: [not available]By: Katrin, S.K.; Michael, M.; Michael, B.; et al.Group Author(s): the Brighton Collaboration Fever Working GroupFever a er Immunization: Current Comcepts and Improved Future Scientific Understanding  Published: 2004Publisher: Infectious Diseases Society of America, Arlington, VA, USA[Show additional data]Times Cited: 1  Assessment and management of pain in infantsBy: Mathew, PJ; Mathew, JLPOSTGRADUATE MEDICAL JOURNAL  Volume: 79   Issue: 934   Pages: 438-443   Published: AUG 1 2003Times Cited: 46  Routine Use of Paracetamol (Acetaminophen) A er Vaccination Not Recommended for Infants, StudyBy: Paddock, C.Medical News Today  Published: 19 October 2009Times Cited: 5  Breastfeeding and Risk for Fever A er ImmunizationBy: Pisacane, Alfredo; Continisio, Paola; Palma, Orsola; et al.PEDIATRICS  Volume: 125   Issue: 6   Pages: E1448-E1452   Published: JUN 2010Times Cited: 8  Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children:two open-label, randomised controlled trialsBy: Prymula, Roman; Siegrist, Claire-Anne; Chlibek, Roman; et al.LANCET  Volume: 374   Issue: 9698   Pages: 1339-1350   Published: OCT 17 2009Times Cited: 170  An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugatevaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus,and Haemophilus influenzae type b vaccineBy: Rose, Markus A.; Juergens, Christine; Schmoele-Thoma, Beate; et al.BMC PEDIATRICS  Volume: 13     Article Number: 98   Published: JUN 21 2013Times Cited: 10  Intermittent clobazam therapy in febrile seizuresBy: Rose, Winsley; Kirubakaran, Chellam; Scott, Julius XavierIndian Journal of Pediatrics  Volume: 72   Issue: 1   Pages: 31-33   Published: January 2005Times Cited: 24  EFFECT OF PROPHYLACTIC ACETAMINOPHEN ADMINISTRATION ON REACTION TO DTP VACCINATIONBy: UHARI, M; HIETALA, J; VILJANEN, MKACTA PAEDIATRICA SCANDINAVICA  Volume: 77   Issue: 5   Pages: 747-751   Published: SEP 1988Times Cited: 20  Showing 18 of 18 View All in Cited References page10.11.12.13.14.15.16.17.18.ClarivateAccelerating innovation© 2019 Clarivate Copyright notice Terms of use Privacy statement Cookie policySign up for the Web of Science newsletter Follow us  

The relevancy of paracetamol and breastfeeding post infant vaccination: A systematic review

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The relevancy of paracetamol and breastfeeding post infant vaccination: A systematic review

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